Instituto Nacional de Psiquiatría, México.
Pharm Biol. 2010 Jan;48(1):70-5. doi: 10.3109/13880200903046153.
This study evaluated possible CNS effects of a hexane extract of leaves from Rollinia mucosa (Jacq.) Baill. (Annonaceae). This plant extract induced anxiolytic-like actions similar to those induced by diazepam in the avoidance exploratory behavior paradigm. Its significant activity was shown at doses from 1.62 to 6.25 mg/kg. It also enhanced pentobarbital-induced hypnosis time, and at high doses produced motor coordination impairment. The benzodiazepine (BDZ) receptor binding, evaluated by in vitro autoradiography following a single administration of R. mucosa, revealed that this plant extract reduced BDZ binding in the hippocampus (29%), amygdala (26%), and temporal cortex of mice (36%). In conclusion, the present findings support the proposal that R. mucosa may induce central nervous system (CNS) depressant effects, presumably through an interaction with the GABA/benzodiazepine receptor complex.
本研究评估了罗尼尼亚黏膜（Jacq.）Baill.（番荔枝科）叶的己烷提取物对中枢神经系统（CNS）的可能影响。这种植物提取物在回避性探索行为范式中引起了类似于地西泮的抗焦虑样作用。其显著的活性在 1.62 至 6.25 mg/kg 的剂量下显示出来。它还增强了戊巴比妥诱导的催眠时间，并且在高剂量下产生运动协调障碍。单次给予罗尼尼亚黏膜后通过体外放射自显影评估的苯二氮䓬（BDZ）受体结合表明，这种植物提取物减少了小鼠海马体（29％）、杏仁核（26％）和颞叶皮质（36％）中的 BDZ 结合。总之，目前的研究结果支持这样的观点，即罗尼尼亚黏膜可能通过与 GABA/苯二氮䓬受体复合物相互作用引起中枢神经系统（CNS）抑制作用。
