Department of Women's and Children's Health, Uppsala University, University Hospital, Uppsala, Sweden.
Gynecol Endocrinol. 2011 Jul;27(7):486-90. doi: 10.3109/09513590.2010.501880. Epub 2010 Jul 21.
IgM antibodies against phosphorylcholine (IgM anti-PC) are natural autoantibodies, possibly exerting one of the atheroprotective functions of the immune system. Increased levels of these antibodies reduce the development of atherosclerosis in mice, and low levels of IgM anti-PC have been associated with increased risk for cardiovascular disease (CVD). This study compared levels of IgM anti-PC in women with polycystic ovary syndrome (PCOS, n = 111) and healthy controls (n = 79).
Levels of IgM anti-PC were measured with ELISA.
The median level of IgM anti-PC in patients with PCOS was not significantly different compared to control subjects. However, the proportion of patients with PCOS with low levels of IgM anti-PC, defined as number of individuals below the median level, was significantly higher than among healthy controls, p < 0.05. Patients with PCOS in the oldest age quintile had significantly lower level of IgM anti-PC than control subjects of similar age (p < 0.05) and younger women with PCOS (p < 0.01).
Our results indicate that women with PCOS more frequently display below-median levels of IgM anti-PC than controls and older women with PCOS have lower median anti-PC levels. Further studies of how this finding translates into actual CVD risk in women with PCOS are needed.
针对磷酸胆碱的 IgM 抗体（IgM 抗-PC）是天然的自身抗体，可能发挥免疫系统的一种抗动脉粥样硬化功能。这些抗体水平的升高可减少小鼠动脉粥样硬化的发展，而 IgM 抗-PC 水平较低与心血管疾病（CVD）风险增加相关。本研究比较了多囊卵巢综合征（PCOS，n = 111）患者和健康对照者（n = 79）的 IgM 抗-PC 水平。
采用 ELISA 法检测 IgM 抗-PC 水平。
与对照组相比，PCOS 患者的 IgM 抗-PC 中位数水平没有显著差异。然而，PCOS 患者中 IgM 抗-PC 水平较低（定义为低于中位数水平的个体数）的比例明显高于健康对照组，p < 0.05。处于年龄最高五分位的 PCOS 患者的 IgM 抗-PC 水平明显低于同龄的对照组受试者（p < 0.05）和较年轻的 PCOS 患者（p < 0.01）。
我们的结果表明，与对照组相比，PCOS 患者更频繁地表现出低于中位数的 IgM 抗-PC 水平，而年龄较大的 PCOS 患者的中位数抗-PC 水平较低。需要进一步研究这一发现如何转化为 PCOS 女性的实际 CVD 风险。
