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慢性锂盐治疗导致的一种奇异心电图模式。

A bizarre electrocardiographic pattern due to chronic lithium therapy.

作者信息

Kayrak Mehmet, Duman Cetin, Gul Enes Elvin, Sonmez Osman, Kaya Zeynettin, Ari Hatem

机构信息

Department of Cardiology, Selcuk University, Konya, Turkey.

出版信息

Ann Noninvasive Electrocardiol. 2010 Jul;15(3):289-92. doi: 10.1111/j.1542-474X.2010.00366.x.

Abstract

Cardiotoxicity that results from lithium overdose is uncommon and electrocardiographic (ECG) changes are rarely reported. However, some authors have specifically reported the occurrence of ischemic ECG changes due to a lithium overdose. This article describes a case that is demonstrating ECG changes that mimic inferior myocardial infarction during the course of chronic lithium treatment and showing QTc prolongation in this patient. The patients' ECG changes were partially recovered after hemodialysis.

摘要

锂过量导致的心脏毒性并不常见,且很少有心电图(ECG)改变的报道。然而,一些作者专门报道了锂过量导致缺血性ECG改变的情况。本文描述了一例在慢性锂治疗过程中出现类似下壁心肌梗死的ECG改变且该患者出现QTc延长的病例。患者的ECG改变在血液透析后部分恢复。

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本文引用的文献

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Unmasking of brugada syndrome by lithium.锂诱发的Brugada综合征的暴露
Circulation. 2005 Sep 13;112(11):1527-31. doi: 10.1161/CIRCULATIONAHA.105.548487. Epub 2005 Sep 6.
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Lithium concentration correlates with QTc in patients with psychosis.精神病患者的锂浓度与QTc相关。
J Electrocardiol. 2005 Apr;38(2):148-51. doi: 10.1016/j.jelectrocard.2004.10.004.
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Psychotropic drugs and the ECG: focus on the QTc interval.精神药物与心电图:关注QTc间期
Expert Opin Pharmacother. 2002 May;3(5):479-98. doi: 10.1517/14656566.3.5.479.
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Prolongation of the Q-T interval in lithium toxicity.锂中毒时Q-T间期延长。
J Electrocardiol. 1979 Jan;12(1):117-9. doi: 10.1016/s0022-0736(79)80054-0.

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