Department of Physiology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
J Neuroendocrinol. 2010 Jul;22(7):736-42. doi: 10.1111/j.1365-2826.2010.02021.x.
Gonadal steroid hormones exert permanent organisational effects on the developing brain and thereby direct adult hormonal responsiveness to dictate sex-specific behaviour and physiology. Considerable progress has been made in elucidating the cellular mechanism of action of androgens and oestrogens during the perinatal sensitive period during which organisation occurs. This review highlights the findings obtained with respect to differential cell death and synaptogenesis with an emphasis on region-specific mechanisms that involve diverse signalling molecules including tumour necrosis factor-alpha, BAX, GABA, glutamate, prostaglandin E(2), FAK and paxillin.
性腺类固醇激素对发育中的大脑产生永久性的组织效应，从而直接影响成年后的激素反应，决定性别特异性的行为和生理。在组织发生的围产期敏感时期，阐明雄激素和雌激素的细胞作用机制方面已经取得了相当大的进展。本综述重点介绍了关于细胞死亡和突触发生的差异的研究结果，强调了涉及多种信号分子的区域特异性机制，包括肿瘤坏死因子-α、BAX、GABA、谷氨酸、前列腺素 E(2)、FAK 和桩蛋白。
