Salomaa V V, Jauhiainen M, Pietinen P, Korhonen H J, Kartovaara L, Vartiainen E, Tuomilehto J
Department of Epidemiology, National Public Health Institute, Helsinki, Finland.
Atherosclerosis. 1991 Jan;86(1):39-48. doi: 10.1016/0021-9150(91)90097-m.
High density lipoprotein cholesterol (HDLC) was measured in the population surveys carried out in Finland in 1982 and 1987. The mean (+/- SD) of HDLC for men aged 25-64 years was 1.23 +/- 0.32 mmol/l in 1982 and 1.30 +/- 0.33 mmol/l in 1987, the increase being 5.7%. Respective values in women were 1.46 +/- 0.33 mmol/l and 1.58 +/- 0.35 mmol/l, an increase of 8.2%. The increase was significantly greater in women than in men (P less than 0.001). The prevalence of low HDLC (less than or equal to 0.9 mmol/l) fell from 13.5 to 9.6% in men and from 3.2 to 1.4% in women. Factors associated with low HDLC were the history of ischemic heart disease (IHD), diabetes and hypertension in both sexes and the positive family history of IHD in women. Subjects with low HDLC also had higher body mass index (BMI), waist-hip ratio and serum total cholesterol (TC) concentration than subjects with normal HDLC. Changes in BMI, waist-hip ratio, alcohol intake, leisure time physical activity, prevalence of smoking or in the dietary variables recorded, did not explain the increase in HDLC.
1982年和1987年在芬兰开展的人群调查中对高密度脂蛋白胆固醇（HDLC）进行了测量。1982年，25 - 64岁男性的HDLC均值（±标准差）为1.23±0.32毫摩尔/升，1987年为1.30±0.33毫摩尔/升，增幅为5.7%。女性的相应数值分别为1.46±0.33毫摩尔/升和1.58±0.35毫摩尔/升，增幅为8.2%。女性的增幅显著高于男性（P<0.001）。HDLC低（≤0.9毫摩尔/升）的患病率在男性中从13.5%降至9.6%，在女性中从3.2%降至1.4%。与HDLC低相关的因素在两性中均为缺血性心脏病（IHD）病史、糖尿病和高血压，在女性中还有IHD的阳性家族史。HDLC低的受试者的体重指数（BMI）、腰臀比和血清总胆固醇（TC）浓度也高于HDLC正常的受试者。BMI、腰臀比、酒精摄入量、休闲时间身体活动、吸烟患病率或所记录的饮食变量的变化均无法解释HDLC的升高。
