Latha M S, Vijayammal P L, Kurup P A
Department of Biochemistry, University of Kerala, Trivandrum, India.
Atherosclerosis. 1991 Jan;86(1):49-54. doi: 10.1016/0021-9150(91)90098-n.
Prolonged exposure of rats to cigarette smoke resulted in significant alteration in the metabolism of glycosaminoglycans (GAG) and glycoproteins (GP). The concentration of many GAG fractions generally decreased in the aorta, liver and heart, but increased in the lungs. Concentration of chondroitin sulphates decreased in all the tissues. The activity of many enzymes concerned with the degradation of GAG (hyaluronidase, beta-glucuronidase and cathepsin-D) showed increase in these tissues. The concentration of the carbohydrate components (total hexose fucose and sialic acid) of aorta, heart and liver showed decrease in the rats exposed to cigarette smoke while there was increase in the lungs. The activity of many glycohydrolases generally showed increase in these tissues. Thus, exposure of rats to cigarette smoke for long periods produced changes in the aortic GAG and GP which are similar to those observed in atherosclerosis. On the other hand there was accumulation of many GAG in the lung tissue.
大鼠长期暴露于香烟烟雾中会导致糖胺聚糖（GAG）和糖蛋白（GP）代谢发生显著改变。许多GAG组分的浓度在主动脉、肝脏和心脏中通常降低，但在肺中升高。硫酸软骨素的浓度在所有组织中均降低。许多与GAG降解相关的酶（透明质酸酶、β-葡萄糖醛酸酶和组织蛋白酶-D）的活性在这些组织中显示增加。暴露于香烟烟雾的大鼠的主动脉、心脏和肝脏中碳水化合物成分（总己糖、岩藻糖和唾液酸）的浓度降低，而肺中则升高。许多糖水解酶的活性在这些组织中通常显示增加。因此，大鼠长期暴露于香烟烟雾会使主动脉GAG和GP发生变化，这些变化与动脉粥样硬化中观察到的变化相似。另一方面，肺组织中积累了许多GAG。
