[The study of association between spontaneous intracranial hemorrhage and cerebral amyloid angiopathy].

OBJECTIVE

To get the general situation of the cerebral amyloid angiopathy (CAA) incidence in spontaneous intracranial hemorrhage (SICH) patients receiving surgical treatment in Chinese people.

METHODS

During the period May 2008 and March 2009, 105 patients admitted to 30 hospitals throughout China for acute SICH were studied, including 68 male and 37 female mean aged (55 +/- 13). The patients were suffered from SICH proved by computed tomography scan (CT). Emergent craniotomies for hemorrhage evacuation were performed for these patients within 72 h after hemorrhage onset and brain tissue of the cortex was also obtained meanwhile. A further histological study, Congo red stained and Abeta immunochemistry included was followed to verify the existence of CAA.

RESULT

Fifteen out of the 105 cases is identified as CAA positive, and the total ratio is 14.29%. As to age groups, about 20.83% (5/24) of the cases of the 40-49 years old group have been diagnosed as CAA, 17.14% (6/35) of the 50-59 years old group, 4.17% (1/24) of the 60-69 group, and for those older than 70 years, the ratio is 8.00% (2/25).

CONCLUSION

We come to the conclusion that 14.29% of the surgically treated SICH events might be closely related to CAA.