National Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorders, Aoi-ku, Shizuoka, Japan.
Epilepsy Behav. 2010 Aug;18(4):381-7. doi: 10.1016/j.yebeh.2010.04.045. Epub 2010 Jun 19.
The aim of epilepsy treatment is not only to eliminate seizures, but also to improve health-related quality of life (HRQOL). We conducted a postal self-administered survey of HRQOL for Japanese patients using the Quality of Life in Epilepsy inventory (QOLIE-31), Version 1.0, and analyzed factors influencing their quality of life (QOL). Data from 599 analyzable patients were evaluated and a number of factors influencing QOL were identified, including severity and frequency of seizures, seizure control, type of epilepsy, contributing events such as injuries and falls during seizures, number of antiepileptic drugs, employment status, and surgical outcome. These findings suggest that comprehensive management of the patient should be emphasized. Consideration of all the results led to classification of these factors as one of two types: "all or nothing" and "linear." With respect to "all or nothing" factors (e.g. "daytime remarkable seizures"), patients may not be able to improve their QOL unless these factors can be completely controlled. Comparison of each score on the QOLIE-31 subscales with published data revealed that the scores for the subscale Medication Effects were markedly low.
癫痫治疗的目的不仅在于消除癫痫发作，还在于提高与健康相关的生活质量（HRQOL）。我们使用癫痫生活质量量表（QOLIE-31）第 1.0 版对日本患者进行了邮寄自我管理的 HRQOL 调查，并分析了影响其生活质量（QOL）的因素。评估了 599 例可分析患者的数据，并确定了一些影响 QOL 的因素，包括癫痫发作的严重程度和频率、癫痫发作的控制情况、癫痫类型、癫痫发作时受伤和跌倒等诱发事件、抗癫痫药物的数量、就业状况和手术结果。这些发现表明应强调对患者进行全面管理。综合考虑所有结果后，将这些因素分为两种类型：“全有或全无”和“线性”。对于“全有或全无”因素（例如“白天明显发作”），除非这些因素能够完全控制，否则患者可能无法提高其 QOL。将 QOLIE-31 子量表的每个评分与已发表的数据进行比较，结果显示药物效应子量表的评分明显较低。
