Department of Psychiatry, College of Medicine and Health Science, University of Gondar, PO Box 196, Gondar, Ethiopia.
Department of Psychiatry, School of Medicine, College of Medicine and Health Science, University of Gondar, Gondar, Ethiopia.
BMC Public Health. 2024 Jun 7;24(1):1529. doi: 10.1186/s12889-024-19018-3.
Epilepsy is a global health and economic burden with major problems that have an impact on physical, psychological, and social activities. Quality of life (QoL) is often disturbed and can be influenced by many factors, like anti-seizure medication side effects, the sociocultural environment, and various disease-related factors. The aim of this systematic review and meta-analysis is to provide an overview of the most recent information available regarding the pooled prevalence of poor quality of life and associated factors among adult people with epilepsy in Ethiopia.
The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) is an appropriate set of guidelines for reporting systematic reviews and meta-analyses. This systematic review and meta-analysis protocol was registered on the International Prospective Register of Systematic Reviews (PROSPERO) with CRD42024527914. To find publications for the systematic review and meta-analysis, we used both manual and electronic searches. The publications were searched by PubMed, MEDLINE, EMBASE, Cochrane Library, Scopus, and other grey publications were searched by Google Scholar. The Joanna Briggs Institute (JBI) for cross-sectional study quality assessment was employed to evaluate the methodological quality of the studies included in this review. The data was extracted in Microsoft Excel, and then it was exported into STATA 11.0 for analysis. A funnel plot and an objective examination of Egger's regression test were used to check for publication bias.
We have included 7 studies conducted in Ethiopia with 2123 study participants, of whom 1163 (54.78%) were male individuals, and 1196 (56.34%) of the participants were living without marriage (either single, divorced, or widowed). The pooled prevalence of poor quality of life among people with epilepsy in Ethiopia is 45.07 (95% CI: 39.73-50.42%). Further, in subgroup analysis regarding the assessment tool of poor quality of life of people with epilepsy, QOLIE-31 accounted for 50.05% (95%CI: 46.65-53.45) and WHO QOL BREF accounted for 39.72% (95%CI: 27.67-51.78). Among the associated factors, being unable to read and write, anxiey and depression were significantly linked to the quality of life of people with epilepsy.
This review found that there was a high pooled prevalence of poor quality of life related to people with epilepsy in Ethiopia. This study may provide further information to concerned bodies that do early screening and manage the quality of life of individuals with epilepsy. Also, screening and intervention for anxiety and depression problems should be considered in regular epilepsy care management.
癫痫是一种全球性的健康和经济负担，存在着许多重大问题，这些问题会影响到身体、心理和社会活动。生活质量（QoL）经常受到干扰，并且可能受到许多因素的影响，如抗癫痫药物的副作用、社会文化环境以及各种与疾病相关的因素。本系统评价和荟萃分析的目的是提供最新的信息，了解埃塞俄比亚成年癫痫患者生活质量不佳的普遍程度及其相关因素。
系统评价和荟萃分析的首选报告项目（PRISMA）是报告系统评价和荟萃分析的一套适当指南。本系统评价和荟萃分析方案已在国际前瞻性系统评价登记处（PROSPERO）注册，注册号为 CRD42024527914。为了查找系统评价和荟萃分析的出版物，我们同时进行了手动和电子搜索。通过 PubMed、MEDLINE、EMBASE、Cochrane 图书馆、Scopus 以及其他灰色文献数据库（如 Google Scholar）搜索出版物。采用 Joanna Briggs 研究所（JBI）的横断面研究质量评估工具来评估本综述中纳入研究的方法学质量。使用 Microsoft Excel 提取数据，然后将其导出到 STATA 11.0 进行分析。使用漏斗图和 Egger 回归检验的客观检查来检查发表偏倚。
我们纳入了 7 项在埃塞俄比亚开展的研究，共涉及 2123 名研究参与者，其中 1163 名（54.78%）为男性，1196 名（56.34%）参与者未婚（单身、离婚或丧偶）。埃塞俄比亚癫痫患者生活质量不佳的总体患病率为 45.07%（95%CI：39.73-50.42%）。此外，在针对癫痫患者生活质量评估工具的亚组分析中，QOLIE-31 占 50.05%（95%CI：46.65-53.45），而 WHOQOL-BREF 占 39.72%（95%CI：27.67-51.78）。在相关因素中，无法读写、焦虑和抑郁与癫痫患者的生活质量显著相关。
本研究发现，埃塞俄比亚癫痫患者生活质量不佳的总体患病率较高。本研究可能为相关机构提供进一步信息，以便对癫痫患者进行早期筛查和管理。此外，在常规癫痫护理管理中应考虑筛查和干预焦虑和抑郁问题。
