中国宣威市炉灶改良前后吸烟对肺癌死亡率的差异影响。
Differential effects of smoking on lung cancer mortality before and after household stove improvement in Xuanwei, China.
机构信息
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
出版信息
Br J Cancer. 2010 Aug 24;103(5):727-9. doi: 10.1038/sj.bjc.6605791. Epub 2010 Jul 20.
Abstract
BACKGROUND
In Xuanwei County, Yunnan Province, China, lung cancer mortality rates in both males and females are among the highest in China.
METHODS
We evaluated differential effects of smoking on lung cancer mortality before and after household stove improvement with chimney to reduce exposure to smoky coal emissions in the unique cohort in Xuanwei, China. Effects of independent variables on lung cancer mortality were measured as hazard ratios and 95% confidence intervals using a multivariable Cox regression model that included separate time-dependent variables for smoking duration (years) before and after stove improvement.
RESULTS AND CONCLUSION
We found that the effect of smoking on lung cancer risk becomes considerably stronger after chimney installation and consequent reduction of indoor coal smoke exposure.
摘要
背景
在中国云南省宣威县，男性和女性的肺癌死亡率均位居全国之首。
方法
我们评估了在改善带烟囱的家用炉灶以减少烟熏煤排放暴露后，吸烟对肺癌死亡率的差异影响，该研究在宣威这一独特队列中进行。使用多变量 Cox 回归模型，通过分别设立与炉灶改善前后吸烟年限（年）相关的时间依赖性变量，以危害比和 95%置信区间来衡量自变量对肺癌死亡率的影响。
结果与结论
我们发现，安装烟囱以及随之而来的室内煤烟暴露减少后，吸烟对肺癌风险的影响明显增强。
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