肽基甘氨酸 α-酰胺化单加氧酶和铜：对神经系统功能至关重要的基因-营养相互作用。
Peptidylgycine α-amidating monooxygenase and copper: a gene-nutrient interaction critical to nervous system function.
机构信息
University of Connecticut Health Center, Farmington, Connecticut 06030-3401, USA.
出版信息
J Neurosci Res. 2010 Sep;88(12):2535-45. doi: 10.1002/jnr.22404.
Abstract
Peptidylgycine alpha-amidating monooxygenase (PAM), a highly conserved copper-dependent enzyme, is essential for the synthesis of all amidated neuropeptides. Biophysical studies revealed that the binding of copper to PAM affects its structure, and cell biological studies demonstrated that the endocytic trafficking of PAM was sensitive to copper. We review data indicating that genetic reduction of PAM expression and mild copper deficiency in mice cause similar alterations in several physiological functions known to be regulated by neuropeptides: thermal regulation, seizure sensitivity, and anxiety-like behavior.
摘要
肽基甘氨酸 α-酰胺化单加氧酶（PAM）是一种高度保守的铜依赖性酶，对于所有酰胺化神经肽的合成都是必不可少的。生物物理研究表明，铜与 PAM 的结合会影响其结构，细胞生物学研究表明 PAM 的内吞运输对铜敏感。我们综述了数据表明，在小鼠中降低 PAM 的表达和轻度铜缺乏会导致几种已知受神经肽调节的生理功能发生类似的改变：体温调节、癫痫易感性和焦虑样行为。
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