Shen Xiaochang, Wang Jiandong, Deng Boer, Zhao Ziyi, Chen Shuning, Kong Weimin, Zhou Chunxiao, Bae-Jump Victoria
Department of Gynecologic Oncology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing 100006, China.
Division of Gynecologic Oncology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Antioxidants (Basel). 2024 May 19;13(5):617. doi: 10.3390/antiox13050617.
Ascorbate (vitamin C) is an essential vitamin for the human body and participates in various physiological processes as an important coenzyme and antioxidant. Furthermore, the role of ascorbate in the prevention and treatment of cancer including gynecological cancer has gained much more interest recently. The bioavailability and certain biological functions of ascorbate are distinct in males versus females due to differences in lean body mass, sex hormones, and lifestyle factors. Despite epidemiological evidence that ascorbate-rich foods and ascorbate plasma concentrations are inversely related to cancer risk, ascorbate has not demonstrated a significant protective effect in patients with gynecological cancers. Adequate ascorbate intake may have the potential to reduce the risk of human papillomavirus (HPV) infection and high-risk HPV persistence status. High-dose ascorbate exerts antitumor activity and synergizes with chemotherapeutic agents in preclinical cancer models of gynecological cancer. In this review, we provide evidence for the biological activity of ascorbate in females and discuss the potential role of ascorbate in the prevention and treatment of ovarian, endometrial, and cervical cancers.
抗坏血酸（维生素C）是人体必需的维生素，作为重要的辅酶和抗氧化剂参与各种生理过程。此外，抗坏血酸在包括妇科癌症在内的癌症预防和治疗中的作用最近受到了更多关注。由于瘦体重、性激素和生活方式因素的差异，抗坏血酸的生物利用度和某些生物学功能在男性和女性中有所不同。尽管有流行病学证据表明富含抗坏血酸的食物和血浆抗坏血酸浓度与癌症风险呈负相关，但抗坏血酸在妇科癌症患者中并未显示出显著的保护作用。充足的抗坏血酸摄入量可能有降低人乳头瘤病毒（HPV）感染风险和高危HPV持续状态的潜力。在妇科癌症的临床前癌症模型中，高剂量抗坏血酸具有抗肿瘤活性并与化疗药物协同作用。在本综述中，我们提供了抗坏血酸在女性中的生物学活性证据，并讨论了抗坏血酸在卵巢癌、子宫内膜癌和宫颈癌预防和治疗中的潜在作用。
