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[并指畸形的遗传特征]

[Inheritance characteristics of syndactylia].

作者信息

Parshchikova L S, Reĭderman M I

出版信息

Genetika. 1977;13(1):162-4.

PMID:206487
Abstract

On the basis of the analysis of 39 pedigrees with syndactylies it is concluded an autosomal dominant mode of the inheritance with incomplete penetrance. The variability of penetrance is more pronounced in females who are frequently healthy carriers of the gene transmitting it to both sexes. The significant prevalence of males in syndactylies can be explained by deathes of female embryos in utero, the sex ratio in healthy sibses being normal.

摘要

在对39个并指(趾)家系进行分析的基础上,得出其遗传方式为常染色体显性遗传且外显不全。外显率的变异性在女性中更为明显,她们常为该基因的健康携带者,并将其传递给两性。并指(趾)中男性的显著高发可由子宫内女性胚胎死亡来解释,健康同胞的性别比例正常。

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