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[生物体对活性氧的防御]

[Organism defense against reactive oxygen species].

作者信息

Puzanowska-Tarasiewicz Helena, Kuźmicka Ludmiła, Tarasiewicz Mirosław

机构信息

Zakład Nauk Chemicznych Wyzszej Szkoły Kosmetologii i Ochrony Zdrowia w Białymstoku.

出版信息

Wiad Lek. 2009;62(4):248-56.

Abstract

Reactive oxygen species (ROS) are constantly formed as side products of biological reactions in which electron transfer goes on. ROS include superoxide anion radical O2*, hydroxide radical OH, hydrogensuperoxide radical HO2, hydrogen peroxide and singlet oxygen. The maintenance of homeostasis at the redox level is particularly important for many biological processes such as: DNA synthesis, enzymes activation and regulation genes, regulation of cellular cycle and programmed death of the cell. Cells protect themselves against oxidative stress by means of antioxidants enzymes and compounds which in their structure have redox sensitive spots.

摘要

活性氧(ROS)作为生物反应的副产物不断形成,其中电子转移持续进行。ROS包括超氧阴离子自由基O2*、羟基自由基OH、过氧化氢自由基HO2、过氧化氢和单线态氧。氧化还原水平的稳态维持对于许多生物过程尤为重要,例如:DNA合成、酶的激活和基因调控、细胞周期调控以及细胞程序性死亡。细胞通过抗氧化酶和结构上具有氧化还原敏感位点的化合物来保护自己免受氧化应激的影响。

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