Morrison L M, Payne M, Drummond G B
Department of Anaesthetics, Royal Infirmary of Edinburgh.
Br J Anaesth. 1991 Jun;66(6):656-9. doi: 10.1093/bja/66.6.656.
In a random, double-blind crossover trial using an ischaemic limb pain model we have assessed the speed of onset of analgesia after an i.v. bolus of equipotent doses of diamorphine and morphine in 12 healthy male volunteers. Pain and its subsequent relief were assessed by means of a visual analogue scale. Two of the subjects found diamorphine acted quicker than morphine, one found no difference and nine found that morphine was quicker than diamorphine. The mean time to diamorphine effect was 53% greater than for morphine (P less than 0.005, Wilcoxon rank sum test). These findings suggest that, for rapid relief of pain, morphine is more suitable than diamorphine.
在一项使用缺血性肢体疼痛模型的随机、双盲交叉试验中，我们评估了12名健康男性志愿者静脉注射等效剂量的海洛因和吗啡后镇痛起效的速度。疼痛及其随后的缓解通过视觉模拟量表进行评估。两名受试者发现海洛因的起效比吗啡快，一名受试者发现没有差异，九名受试者发现吗啡比海洛因快。海洛因起效的平均时间比吗啡长53%（P<0.005，Wilcoxon秩和检验）。这些发现表明，为了快速缓解疼痛，吗啡比海洛因更合适。
