Brophy C M, Reilly J M, Smith G J, Tilson M D
Department of Surgery, New England Deaconess Hospital, Boston, Massachusetts 02215.
Ann Vasc Surg. 1991 May;5(3):229-33. doi: 10.1007/BF02329378.
The predominant pathologic feature of abdominal aortic aneurysm is elastin destruction, and elastin destruction may be mediated by inflammation. In this investigation serial sections of abdominal aortic aneurysm specimens were selectively stained to study the relationship between inflammation and elastin degradation. In addition, soluble aortic extracts were examined for the presence of immunoglobulins. An inflammatory infiltrate was present in 8 of 10 of the abdominal aortic aneurysm specimens examined. The infiltrate was mononuclear, commonly located at the junction of the media and adventitia; it did not codistribute with loss of elastin. The presence of an inflammatory component in abdominal aortic aneurysm was associated with a large amount of immunoglobulin in soluble extracts from aneurysmal tissue compared to atherosclerotic and normal control extracts. This study further characterizes the microscopic pathology of abdominal aortic aneurysm and describes the presence of immunoglobulin in soluble tissue extracts. In addition, the possible role of inflammation in abdominal aortic aneurysm as it relates to protease expression is detailed.
腹主动脉瘤的主要病理特征是弹性蛋白破坏，且弹性蛋白破坏可能由炎症介导。在本研究中，对腹主动脉瘤标本的连续切片进行选择性染色，以研究炎症与弹性蛋白降解之间的关系。此外，检测了可溶性主动脉提取物中免疫球蛋白的存在情况。在所检查的10例腹主动脉瘤标本中，有8例存在炎性浸润。浸润为单核细胞，通常位于中膜和外膜交界处；它与弹性蛋白缺失不同步分布。与动脉粥样硬化和正常对照提取物相比，腹主动脉瘤中炎症成分的存在与动脉瘤组织可溶性提取物中大量免疫球蛋白有关。本研究进一步描述了腹主动脉瘤的微观病理学，并描述了可溶性组织提取物中免疫球蛋白的存在情况。此外，还详细阐述了炎症在腹主动脉瘤中与蛋白酶表达相关的可能作用。
