Department of Medicine, Schools of Medicine and Public Health, University of Washington, 325 Ninth Avenue, Seattle, WA 98104, USA.
J Infect Dis. 2010 Sep 1;202(5):734-8. doi: 10.1086/655662.
We evaluated whether acyclovir suppression during human immunodeficiency virus type 1 (HIV-1) acquisition reduces HIV-1 set point, increases CD4 cell counts, and selects reverse-transcriptase mutations among 76 HIV-1 seroconverters identified in a placebo-controlled trial of twice-daily acyclovir (400 mg) for the prevention of HIV acquisition in herpes simplex virus type 2 (HSV-2)-seropositive persons (HIV Prevention Trials Network study 039). We found no significant difference in plasma HIV-1 RNA levels (P =.30) or CD4 cell counts (P =.85) between the acyclovir and placebo recipients. V75I and other mutations in HIV-1 reverse transcriptase reported from in vitro acyclovir studies were not observed. In conclusion, acyclovir suppression during HIV-1 seroconversion and the subsequent 6 months does not affect HIV-1 set point.
我们评估了在人类免疫缺陷病毒 1 型(HIV-1)获得期间抑制阿昔洛韦是否会降低 HIV-1 定殖水平,增加 CD4 细胞计数,并在疱疹单纯病毒 2 型(HSV-2)血清阳性者中接受每日两次阿昔洛韦(400mg)预防 HIV 获得的安慰剂对照试验中识别的 76 例 HIV-1 血清转换者中选择逆转录酶突变(HIV 预防试验网络研究 039)。我们发现阿昔洛韦和安慰剂组之间的血浆 HIV-1 RNA 水平(P =.30)或 CD4 细胞计数(P =.85)没有显著差异。在体外阿昔洛韦研究中报告的 HIV-1 逆转录酶中的 V75I 和其他突变未观察到。总之,HIV-1 血清转换期间和随后的 6 个月内抑制阿昔洛韦不会影响 HIV-1 定殖水平。