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Rapid changes in concentrations of essential elements in organs of rats exposed to methylmercury chloride and mercuric chloride as shown by simultaneous multielemental analysis.通过同步多元素分析显示，暴露于氯化甲基汞和氯化汞的大鼠器官中必需元素浓度的快速变化。
Br J Ind Med. 1991 Jun;48(6):382-8. doi: 10.1136/oem.48.6.382.
2
Different histochemical findings in the brain produced by mercuric chloride and methyl mercury chloride in rats.氯化汞和甲基氯化汞对大鼠大脑产生的不同组织化学结果。
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3
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Effect of acute administration of mercuric chloride on the disposition of copper, zinc, and iron in the rat.急性给予氯化汞对大鼠体内铜、锌和铁分布的影响。
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Milk transfer and tissue uptake of mercury in suckling offspring after exposure of lactating maternal guinea pigs to inorganic or methylmercury.哺乳期母豚鼠暴露于无机汞或甲基汞后，其哺乳后代体内汞的乳汁转移及组织摄取情况。
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The effects of prenatal methylmercury exposure on trace element and antioxidant levels in rats following 6-hydroxydopamine-induced neuronal insult.产前甲基汞暴露对6-羟基多巴胺诱导的神经元损伤后大鼠微量元素和抗氧化剂水平的影响。
Metab Brain Dis. 2014 Jun;29(2):459-69. doi: 10.1007/s11011-013-9465-4. Epub 2013 Dec 17.
2
Inorganic mercury exposure, mercury-copper interaction, and DMPS treatment in rats.大鼠的无机汞暴露、汞-铜相互作用及二巯丙磺钠治疗
Environ Health Perspect. 1994 Sep;102 Suppl 3(Suppl 3):305-7. doi: 10.1289/ehp.94102s3305.

本文引用的文献

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The interaction of cadium-induced rat renal metallothionein with bivalent mercury in vitro.
Chem Biol Interact. 1980 Oct;32(1-2):125-35. doi: 10.1016/0009-2797(80)90072-1.
2
Effect of mercuric chloride and methylmercury chloride exposure on tissue concentrations of six essential minerals.氯化汞和甲基氯化汞暴露对六种必需矿物质组织浓度的影响。
Environ Res. 1980 Apr;21(2):350-9. doi: 10.1016/0013-9351(80)90037-7.
3
Metabolism of zinc and copper in the neonate. (Zinc, copper)-thionein in the developing rat kidney and testis.
J Biol Chem. 1981 Apr 25;256(8):3931-5.
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Functions of metallothionein.金属硫蛋白的功能。
Biochem Pharmacol. 1982 Jan 15;31(2):137-42. doi: 10.1016/0006-2952(82)90202-7.
5
Effects of dietary mercury level and cadmium on rat tissue metallothionein: mercury binding and influences on zinc.膳食汞水平和镉对大鼠组织金属硫蛋白的影响：汞结合及对锌的影响
Environ Res. 1983 Apr;30(2):372-80. doi: 10.1016/0013-9351(83)90222-0.
6
Urinary metallothionein and tissue metal levels of rats injected with cadmium, mercury, lead, copper or zinc.注射镉、汞、铅、铜或锌的大鼠的尿金属硫蛋白和组织金属水平
Toxicology. 1983 Jul-Aug;27(3-4):337-45. doi: 10.1016/0300-483x(83)90029-x.
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Hemoglobin-catalyzed lipid peroxidation in the presence of mercuric chloride.
Chem Biol Interact. 1983 Jul 1;45(1):105-12. doi: 10.1016/0009-2797(83)90046-7.
8
Uptake of mercury by the brain.大脑对汞的摄取。
Br J Ind Med. 1968 Oct;25(4):315-8. doi: 10.1136/oem.25.4.315.
9
Fusion of phospholipid vesicles induced by Zn2+, Cd2+, and Hg2+.
Biochem Biophys Res Commun. 1985 Apr 16;128(1):389-95. doi: 10.1016/0006-291x(85)91691-2.
10
Effect of Ca2+, peroxides, SH reagents, phosphate and aging on the permeability of mitochondrial membranes.钙离子、过氧化物、巯基试剂、磷酸盐及老化对线粒体膜通透性的影响。
Eur J Biochem. 1987 Jan 15;162(2):239-49. doi: 10.1111/j.1432-1033.1987.tb10591.x.

通过同步多元素分析显示，暴露于氯化甲基汞和氯化汞的大鼠器官中必需元素浓度的快速变化。

Rapid changes in concentrations of essential elements in organs of rats exposed to methylmercury chloride and mercuric chloride as shown by simultaneous multielemental analysis.

作者信息

Muto H, Shinada M, Tokuta K, Takizawa Y

机构信息

Environmental Research Center, Akita University, Japan.

出版信息

Br J Ind Med. 1991 Jun;48(6):382-8. doi: 10.1136/oem.48.6.382.

DOI:10.1136/oem.48.6.382
PMID:2064976
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1035382/
Abstract

An in vivo study of rats given a dominant lethal dose of methylmercury chloride (MMC) or mercuric chloride (HgCl2) was conducted to elucidate the rapid biotransformation of essential elements. The elements were measured by inductively coupled plasma atomic emission spectrometry. For the rat brain Zn concentrations were higher in the MMC group than in the HgCl2 and control groups. The highest Cu concentration was found in HgCl2 dosed rat liver. For the rat kidney the highest Zn concentration was seen in the MMC group. From principal component analysis on the time dependent behaviour of each element in rat organs, characteristics specific to Cu in the liver and kidney and Mn in the brain were found after exposure to HgCl2 and Ca and Zn in the brain after exposure to MMC.

摘要

为阐明必需元素的快速生物转化过程，开展了一项针对给予大鼠致死剂量氯化甲基汞（MMC）或氯化汞（HgCl₂）的体内研究。通过电感耦合等离子体原子发射光谱法对元素进行测定。对于大鼠大脑，MMC组的锌浓度高于HgCl₂组和对照组。HgCl₂给药组大鼠肝脏中的铜浓度最高。对于大鼠肾脏，MMC组的锌浓度最高。通过对大鼠器官中各元素随时间变化行为的主成分分析发现，暴露于HgCl₂后，肝脏和肾脏中的铜以及大脑中的锰具有特定特征；暴露于MMC后，大脑中的钙和锌具有特定特征。