Macdonald D W, Saggerson E D
Horm Metab Res. 1978 Mar;10(2):135-8. doi: 10.1055/s-0028-1093459.
Renal pyruvate dehydrogenasea activity was measured in suspensions of kidney cortex tubules from fed rats after incubation with various concentrations of Ca2+, 3'5' cyclic AMP or adrenalin. At certain concentrations these agents all decreased pyruvate dehydrogenasea activity and increased glucose formation from pyruvate. There appeared to be some interdependence between the effects of Ca2+ and 3,5, cyclic AMP on pyruvate dehydrogenasea activity. Effects of adrenalin on pyruvate dehydrogenasea activity were no longer observed when palmitate was included in incubations. The possibility that regulation of pyruvate dehydrogenasea may indirectly contribute to the control of gluconeogenesis by influencing pyruvate metabolism is briefly discussed.
在喂食大鼠的肾皮质小管悬浮液中，在与不同浓度的钙离子、3',5'-环磷酸腺苷或肾上腺素孵育后，测定肾丙酮酸脱氢酶a的活性。在某些浓度下，这些试剂均降低了丙酮酸脱氢酶a的活性，并增加了丙酮酸生成葡萄糖的量。钙离子和3',5'-环磷酸腺苷对丙酮酸脱氢酶a活性的影响之间似乎存在某种相互依赖性。当孵育液中加入棕榈酸时，不再观察到肾上腺素对丙酮酸脱氢酶a活性的影响。本文简要讨论了丙酮酸脱氢酶a的调节可能通过影响丙酮酸代谢间接有助于糖异生控制的可能性。
