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1
Effect of adrenalectomy on acceleration of gluconeogenesis by calcium ions, adenosine 3':5'-cyclic monophosphate and adrenaline in rat kidney tubules.肾上腺切除术对钙离子、3':5'-环磷酸腺苷和肾上腺素加速大鼠肾小管糖异生作用的影响。
Biochem J. 1978 Aug 15;174(2):641-6. doi: 10.1042/bj1740641.
2
Hormonal control of gluconeogenesis in tubule fragments from renal cortex of fed rats. Effects of alpha-adrenergic stimuli, glucagon, theophylline and papaverine.进食大鼠肾皮质肾小管片段中糖异生的激素调控。α-肾上腺素能刺激、胰高血糖素、茶碱和罂粟碱的作用。
Biochem J. 1977 Oct 15;168(1):33-42. doi: 10.1042/bj1680033.
3
A study of regulation of gluconeogenesis and the supply of cytosolic reducing equivalents for lactate formation in rat kidney-cortical-tubule fragments incubated with pyruvate.一项关于丙酮酸孵育大鼠肾皮质小管片段中糖异生调节及乳酸生成的胞质还原当量供应的研究。
Biochem J. 1978 Jul 15;174(1):131-42. doi: 10.1042/bj1740131.
4
Regulation of renal gluconeogenesis by calcium ions, hormones and adenosine 3':5'-cyclic monophosphate.钙离子、激素及3':5'-环磷酸腺苷对肾糖异生的调节作用
Biochem J. 1973 May;134(1):157-65. doi: 10.1042/bj1340157.
5
Evidence for stimulation of renal gluconeogenesis by catecholamines.儿茶酚胺刺激肾糖异生的证据。
J Clin Invest. 1973 Apr;52(4):961-4. doi: 10.1172/JCI107261.
6
Metabolism of isolated kidney tubules. Independent actions of catecholamines on renal cyclic adenosine 3':5'-monophosphate levels and gluconeogenesis.离体肾小管的代谢。儿茶酚胺对肾环磷酸腺苷水平和糖异生的独立作用。
Eur J Biochem. 1975 Mar 17;52(2):283-90. doi: 10.1111/j.1432-1033.1975.tb03996.x.
7
Regulation of pyruvate dehydrogenase by Ca2+, 3'5' cyclic AMP and adrenalin in isolated rat kidney tubules.钙离子、3',5'-环磷酸腺苷和肾上腺素对离体大鼠肾小管丙酮酸脱氢酶的调节作用
Horm Metab Res. 1978 Mar;10(2):135-8. doi: 10.1055/s-0028-1093459.
8
Effect of compound D-600 (methoxyverapamil) on gluconeogenesis and on acceleration of the process by alpha-adrenergic stimuli in rat kidney tubules.化合物D - 600（甲氧基维拉帕米）对大鼠肾小管糖异生及α - 肾上腺素能刺激加速该过程的影响。
Biochem J. 1980 Aug 15;190(2):283-91. doi: 10.1042/bj1900283.
9
Ionic control of renal gluconeogenesis. II. The effects of Ca2+ and H+ upon the response to parathyroid hormone and cyclic AMP.肾糖异生的离子调控。II. 钙和氢离子对甲状旁腺激素及环磷酸腺苷反应的影响。
Biochim Biophys Acta. 1973 Jun 20;313(1):32-41. doi: 10.1016/0304-4165(73)90186-4.
10
Gluconeogenesis from glutamine and lactate in the isolated human renal proximal tubule: longitudinal heterogeneity and lack of response to adrenaline.在分离的人肾近端小管中由谷氨酰胺和乳酸生成葡萄糖：纵向异质性及对肾上腺素无反应
Biochem J. 2001 Dec 1;360(Pt 2):371-7. doi: 10.1042/0264-6021:3600371.

引用本文的文献

1
Effect of compound D-600 (methoxyverapamil) on gluconeogenesis and on acceleration of the process by alpha-adrenergic stimuli in rat kidney tubules.化合物D - 600（甲氧基维拉帕米）对大鼠肾小管糖异生及α - 肾上腺素能刺激加速该过程的影响。
Biochem J. 1980 Aug 15;190(2):283-91. doi: 10.1042/bj1900283.
2
Evidence that catecholamines stimulate renal gluconeogenesis through an alpha 1-type of adrenoceptor.儿茶酚胺通过α1型肾上腺素能受体刺激肾糖异生的证据。
Biochem J. 1980 Jul 15;190(1):119-23. doi: 10.1042/bj1900119.

本文引用的文献

1
EFFECT OF METAL IONS ON IN VITRO GLUCONEOGENESIS IN RAT KIDNEY CORTEX SLICES.金属离子对大鼠肾皮质切片体外糖异生的影响。
Am J Physiol. 1965 May;208:842-6. doi: 10.1152/ajplegacy.1965.208.5.841.
2
Renal gluconeogenesis. The effect of diet on the gluconeogenic capacity of rat-kidney-cortex slices.肾糖异生。饮食对大鼠肾皮质切片糖异生能力的影响。
Biochem J. 1963 Jan;86(1):22-7. doi: 10.1042/bj0860022.
3
A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid.用于比色法测定脱氧核糖核酸的二苯胺反应的条件及机制研究。
Biochem J. 1956 Feb;62(2):315-23. doi: 10.1042/bj0620315.
4
Removal of fatty acids from serum albumin by charcoal treatment.通过活性炭处理从血清白蛋白中去除脂肪酸。
J Biol Chem. 1967 Jan 25;242(2):173-81.
5
The interrelationship of the concentration of hydrogen ions, bicarbonate ions, carbon dioxide and calcium ions in the regulation of renal gluconeogenesis in the rat.大鼠肾糖异生调节中氢离子、碳酸氢根离子、二氧化碳和钙离子浓度的相互关系。
Biochem J. 1973 Nov;136(3):445-53. doi: 10.1042/bj1360445.
6
Regulation of renal gluconeogenesis by calcium ions, hormones and adenosine 3':5'-cyclic monophosphate.钙离子、激素及3':5'-环磷酸腺苷对肾糖异生的调节作用
Biochem J. 1973 May;134(1):157-65. doi: 10.1042/bj1340157.
7
Alterations in lipolysis, adenylate cyclase and adenosine 3', 5'-monophosphate levels in isolated fat cells following adrenalectomy.肾上腺切除术后分离脂肪细胞中脂解作用、腺苷酸环化酶及3',5'-单磷酸腺苷水平的变化
Endocrinology. 1972 Aug;91(2):504-10. doi: 10.1210/endo-91-2-504.
8
The regulation of glyceride synthesis in isolated white-fat cells. The effects of palmitate and lipolytic agents.分离的白色脂肪细胞中甘油酯合成的调节。棕榈酸盐和脂解剂的作用。
Biochem J. 1972 Aug;128(5):1057-67. doi: 10.1042/bj1281057.
9
Interaction of glucocorticoids with glucagon and epinephrine in the control of gluconeogenesis and glycogenolysis in liver and of lipolysis in adipose tissue.糖皮质激素与胰高血糖素及肾上腺素在肝脏糖异生和糖原分解以及脂肪组织脂肪分解调控中的相互作用。
J Biol Chem. 1972 Jun 10;247(11):3579-88.
10
Metabolism of isolated kidney tubules. Oxygen consumption, gluconeogenesis and the effect of cyclic nucleotides in tubules from starved rats.离体肾小管的代谢。饥饿大鼠肾小管的耗氧量、糖异生作用及环核苷酸的影响。
Hoppe Seylers Z Physiol Chem. 1971 Oct;352(10):1319-28. doi: 10.1515/bchm2.1971.352.2.1319.

肾上腺切除术对钙离子、3':5'-环磷酸腺苷和肾上腺素加速大鼠肾小管糖异生作用的影响。

Effect of adrenalectomy on acceleration of gluconeogenesis by calcium ions, adenosine 3':5'-cyclic monophosphate and adrenaline in rat kidney tubules.

作者信息

MacDonald D W, Saggerson E D

出版信息

Biochem J. 1978 Aug 15;174(2):641-6. doi: 10.1042/bj1740641.

DOI:10.1042/bj1740641
PMID:213058
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1185958/
Abstract
  1. Gluconeogenesis from pyruvate was measured in renal-cortical-tubules fragments prepared from fed male rats 6-8 days after adrenalectomy or sham adrenalectomy. The response of this process to 3':5'-cyclic AMP and adrenaline was compared in these two states at two Ca2+ concentrations. 2. Adrenalectomy decreased the percentage stimulation of gluconeogenesis by 3':5'-cyclic AMP, but increased percentage stimulation by adrenaline. Cortisol treatment of adrenalectomized rats (50 mg/kg, twice daily for 2 days) did not reverse the change in responsiveness to 3':5'-cyclic AMP and adrenaline. 3. Stimulation of gluconeogenesis by 1 micron-adrenaline was unaffected by 10 micron-propranolol (beta-blocker) in either state. Phentolamine (alpha-blocker; 10 micron) totally blocked stimulation of gluconeogenesis by 1 micron-adrenaline in the sham-operated condition, but was only partially effective in this respect after adrenalectomy.
摘要
  1. 在肾上腺切除或假肾上腺切除术后6 - 8天的雄性成年大鼠制备的肾皮质小管片段中，测定了丙酮酸的糖异生作用。在两种状态下的两种钙离子浓度条件下，比较了该过程对3',5'-环磷酸腺苷和肾上腺素的反应。2. 肾上腺切除术降低了3',5'-环磷酸腺苷对糖异生的刺激百分比，但增加了肾上腺素的刺激百分比。对肾上腺切除大鼠进行皮质醇处理（50 mg/kg，每日两次，共2天）并不能逆转对3',5'-环磷酸腺苷和肾上腺素反应性的变化。3. 在两种状态下，1微摩尔肾上腺素对糖异生的刺激均不受10微摩尔普萘洛尔（β受体阻滞剂）的影响。酚妥拉明（α受体阻滞剂；10微摩尔）在假手术条件下完全阻断了1微摩尔肾上腺素对糖异生的刺激，但在肾上腺切除术后仅部分有效。