肾上腺切除术对钙离子、3':5'-环磷酸腺苷和肾上腺素加速大鼠肾小管糖异生作用的影响。
Effect of adrenalectomy on acceleration of gluconeogenesis by calcium ions, adenosine 3':5'-cyclic monophosphate and adrenaline in rat kidney tubules.
作者信息
MacDonald D W, Saggerson E D
出版信息
Biochem J. 1978 Aug 15;174(2):641-6. doi: 10.1042/bj1740641.
Abstract
- Gluconeogenesis from pyruvate was measured in renal-cortical-tubules fragments prepared from fed male rats 6-8 days after adrenalectomy or sham adrenalectomy. The response of this process to 3':5'-cyclic AMP and adrenaline was compared in these two states at two Ca2+ concentrations. 2. Adrenalectomy decreased the percentage stimulation of gluconeogenesis by 3':5'-cyclic AMP, but increased percentage stimulation by adrenaline. Cortisol treatment of adrenalectomized rats (50 mg/kg, twice daily for 2 days) did not reverse the change in responsiveness to 3':5'-cyclic AMP and adrenaline. 3. Stimulation of gluconeogenesis by 1 micron-adrenaline was unaffected by 10 micron-propranolol (beta-blocker) in either state. Phentolamine (alpha-blocker; 10 micron) totally blocked stimulation of gluconeogenesis by 1 micron-adrenaline in the sham-operated condition, but was only partially effective in this respect after adrenalectomy.
摘要
- 在肾上腺切除或假肾上腺切除术后6 - 8天的雄性成年大鼠制备的肾皮质小管片段中，测定了丙酮酸的糖异生作用。在两种状态下的两种钙离子浓度条件下，比较了该过程对3',5'-环磷酸腺苷和肾上腺素的反应。2. 肾上腺切除术降低了3',5'-环磷酸腺苷对糖异生的刺激百分比，但增加了肾上腺素的刺激百分比。对肾上腺切除大鼠进行皮质醇处理（50 mg/kg，每日两次，共2天）并不能逆转对3',5'-环磷酸腺苷和肾上腺素反应性的变化。3. 在两种状态下，1微摩尔肾上腺素对糖异生的刺激均不受10微摩尔普萘洛尔（β受体阻滞剂）的影响。酚妥拉明（α受体阻滞剂；10微摩尔）在假手术条件下完全阻断了1微摩尔肾上腺素对糖异生的刺激，但在肾上腺切除术后仅部分有效。
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引用本文的文献
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EFFECT OF METAL IONS ON IN VITRO GLUCONEOGENESIS IN RAT KIDNEY CORTEX SLICES.金属离子对大鼠肾皮质切片体外糖异生的影响。
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The interrelationship of the concentration of hydrogen ions, bicarbonate ions, carbon dioxide and calcium ions in the regulation of renal gluconeogenesis in the rat.大鼠肾糖异生调节中氢离子、碳酸氢根离子、二氧化碳和钙离子浓度的相互关系。
Biochem J. 1973 Nov;136(3):445-53. doi: 10.1042/bj1360445.
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Regulation of renal gluconeogenesis by calcium ions, hormones and adenosine 3':5'-cyclic monophosphate.钙离子、激素及3':5'-环磷酸腺苷对肾糖异生的调节作用
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Alterations in lipolysis, adenylate cyclase and adenosine 3', 5'-monophosphate levels in isolated fat cells following adrenalectomy.肾上腺切除术后分离脂肪细胞中脂解作用、腺苷酸环化酶及3',5'-单磷酸腺苷水平的变化
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