Roemer K, Johnson P A, Friedmann T
Center for Molecular Genetics, University of California, San Diego, La Jolla 92093.
New Biol. 1991 Apr;3(4):331-5.
The meeting clearly reflected the recent rapid and staggering progress in the use of transgenic mice. Being able to manipulate single units of genetic information in their natural position in a cell genome and to examine the results of that manipulation in the background of a terminally differentiated organism has been an outstanding achievement on the road toward a deeper and generalizable understanding of complex life forms. However, there are many examples of genetic diseases in humans (for instance, Lesh-Nyhan syndrome, Duchenne muscular dystrophy, phenylketonuria) whose genotypic "equivalent" in transgenic mice results in very different phenotypes or no phenotypic changes at all. Mice are clearly not human beings. Why not? No doubt, we will find out!
这次会议清楚地反映了转基因小鼠应用方面最近取得的迅速且惊人的进展。能够在细胞基因组的自然位置操纵单个遗传信息单元，并在终末分化生物体的背景下检查该操纵的结果，这是在深入且可推广地理解复杂生命形式的道路上取得的一项杰出成就。然而，人类中有许多遗传疾病的例子（例如，莱施-尼汉综合征、杜兴氏肌肉营养不良症、苯丙酮尿症），其在转基因小鼠中的基因型“等效物”会导致非常不同的表型，或者根本没有表型变化。小鼠显然不是人类。为什么不是呢？毫无疑问，我们会找到答案的！
