Department of Occupational Therapy, Tel Aviv University, Israel.
Res Dev Disabil. 2010 Nov-Dec;31(6):1443-7. doi: 10.1016/j.ridd.2010.06.014. Epub 2010 Jul 21.
Attention Deficit Hyperactive Disorder (ADHD) and Developmental Coordination Disorder (DCD) are two developmental disorders with considerable comorbidity. The impact of Methylphenidate (MPH) on ADHD symptoms is well documented. However, the effects of MPH on motor coordination are less studied. We assessed the influence of MPH on motor performance of children with comorbid DCD and ADHD. Participants were 18 children (13 boys, mean age 8.3 years) diagnosed with comorbid DCD and ADHD. A structured clinical interview (K-SADS-PL) was used to determine psychopathology and the Movement Assessment Battery for Children-Checklist were used to determine criterion for motor deficits. The Movement Assessment Battery for Children (M-ABC) was administrated to all participants once under the influence of MPH and once under a placebo pill condition. The motor tests were administered on two separate days in a double-blinded design. Participants' motor performance with MPH was significantly superior to their performance in the placebo condition. Significant improvement was observed in all the M-ABC sub-tasks except for static balance performance. The findings suggest that MPH improves motor coordination in children with comorbid DCD and ADHD but clinically significant improvement was found in only 33% of the children.
注意缺陷多动障碍(ADHD)和发育性协调障碍(DCD)是两种具有相当高共病率的发育障碍。哌醋甲酯(MPH)对 ADHD 症状的影响已有充分记录。然而,MPH 对运动协调的影响研究较少。我们评估了 MPH 对共患 DCD 和 ADHD 儿童运动表现的影响。参与者为 18 名儿童(男 13 名,平均年龄 8.3 岁),诊断为共患 DCD 和 ADHD。采用结构化临床访谈(K-SADS-PL)确定精神病理学,采用儿童运动评估量表-检查表确定运动缺陷标准。所有参与者均在 MPH 影响下和安慰剂丸条件下接受一次儿童运动评估量表(M-ABC)测试。在双盲设计下,在两天内分别进行运动测试。参与者在 MPH 作用下的运动表现明显优于安慰剂条件下的表现。除静态平衡表现外,所有 M-ABC 子任务均观察到显著改善。研究结果表明,MPH 可改善共患 DCD 和 ADHD 儿童的运动协调能力,但只有 33%的儿童出现临床显著改善。