Wu Jiang-Hong, Yan Zu-Wei, Zhang Wen-Guang, Li Jin-Quan
College of Animal Science, Inner Mongolia Agricultural University, Hohhot 010018, China.
Yi Chuan. 2010 Jul;32(7):656-62. doi: 10.3724/sp.j.1005.2010.00656.
Hoxc13 belongs to the Abd-B class of Hox gene family, which participated in the hair follicle formation and hair growth regulation process. The structural protein of hair KP (keratin) and KAP (keratin-associated protein) expression is under regulation of Hoxc13, and then changes the characteristics of hair by regulating the composition of these two types of hair proteins and maintaining the normal morphology of hair follicle. In this review, we summarized that the relationship between the expression level of Hoxc13 and hair follicle development/hair growth and the mechanisim under the controling of Hoxc13 and relevant genes.
Hoxc13属于Hox基因家族的Abd - B类，参与毛囊形成和毛发生长调节过程。毛发角蛋白（KP）和角蛋白相关蛋白（KAP）的结构蛋白表达受Hoxc13调控，进而通过调节这两种毛发蛋白的组成并维持毛囊的正常形态来改变毛发特征。在本综述中，我们总结了Hoxc13表达水平与毛囊发育/毛发生长之间的关系以及Hoxc13与相关基因调控下的机制。
