磁化传递成像是磁共振成像的一种特殊序列，主要用于研究活体组织内水分子的磁化转移特性，通过检测组织内顺磁性物质（如含铁血黄素、自由基、蛋白等）引起的局部磁场不均匀性，来反映组织的病变情况。
Magnetization transfer imaging provides no evidence of demyelination in methotrexate-induced encephalopathy.
机构信息
Institute of Radiology, Center for Child and Adolescent Health, Heinrich-Heine-University, Düsseldorf, Germany.
出版信息
AJNR Am J Neuroradiol. 2011 Jun-Jul;32(6):E110-2. doi: 10.3174/ajnr.A2181. Epub 2010 Jul 22.
Abstract
Subacute MTX-induced encephalopathy is characterized by an abrupt onset of focal neurologic deficits within days after intrathecal or systemic therapy. Demyelination is one proposed mechanism. We describe the neuroimaging features of 2 patients with clinical symptoms of subacute encephalopathy after intrathecal and systemic MTX therapy. DWI showed restricted diffusion, indicating cytotoxic edema. MTI yielded no evidence of demyelination in either patient because there was no loss of MTR in areas of restricted diffusion.
摘要
亚急性 MTX 诱导的脑病的特征是鞘内或全身治疗后数天内突发局灶性神经功能缺损。脱髓鞘是一种提出的机制。我们描述了 2 例接受鞘内和全身 MTX 治疗后出现亚急性脑病临床症状的患者的神经影像学特征。DWI 显示弥散受限，表明细胞毒性水肿。MTI 未在任何患者中发现脱髓鞘的证据，因为弥散受限区域的 MTR 没有丢失。
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