Rubbert-Roth A, Petereit H-F
Medizinische Klinik I, Universität zu Köln, Kerpener Str. 62, 50240, Köln, Deutschland.
Z Rheumatol. 2012 Sep;71(7):572-82. doi: 10.1007/s00393-012-0959-y.
Antirheumatic medication is of crucial importance within the treatment concept of chronic inflammatory disorders. Side effects may affect various organ systems, among which are neurologic manifestations. If patients have comorbidities involving the nervous system this should be taken into consideration before choosing an individual immunosuppressant or immunomodulatory compound, as any worsening of the underlying neurologic disease should be avoided. In this article, relevant neurologic disorders will be described with respect to the clinical manifestations, differential diagnosis and treatment. In the second part, pharmaceuticals and biologicals which are frequently used as part of an antirheumatic regimen are discussed with respect to the potential to induce side effects specifically related to the nervous system.
抗风湿药物在慢性炎症性疾病的治疗理念中至关重要。副作用可能影响多个器官系统，其中包括神经系统表现。如果患者合并有涉及神经系统的疾病，在选择个体免疫抑制剂或免疫调节化合物之前应予以考虑，因为应避免基础神经疾病的任何恶化。在本文中，将从临床表现、鉴别诊断和治疗方面描述相关的神经系统疾病。在第二部分中，将讨论常用于抗风湿治疗方案的药物和生物制剂，分析其诱发与神经系统特异性相关副作用的可能性。
