Odrobina Ewa E, Lam Toby Y J, Pun Teresa, Midha Rajiv, Stanisz Greg J
Imaging Research, Sunnybrook and Women's College Health Science Centre, Toronto, Ontario, Canada.
NMR Biomed. 2005 Aug;18(5):277-84. doi: 10.1002/nbm.951.
Changes in the magnetic resonance (MR) parameters of demyelinated neural tissue were measured in vitro using an experimental animal model. A tellurium (Te) diet was applied to weanling rats to induce the demyelination process in the sciatic nerve. The quantitative MR parameters, such as T(1), T(2) relaxation time constants and magnetization transfer (MT) were measured each day after applying the Te diet (up to 7 days) and were found to be substantially different from those of normal nerves. An increase in the average T(1) and T(2) was observed along with a decrease in the MT ratio (MTR) and the quantitative MT parameter M(0B), which describes the semisolid pool of protons. Most of the MR parameters correlated very well with the myelin fraction of neural tissue evaluated by quantitative histopathology. The T(2) relaxation spectrum provided the most efficient quantitative assessment of changes in neural tissue microstructure and its analysis resulted in a powerful tool to distinguish the processes of demyelination and inflammation. In comparison, the MT measurements were less successful.
使用实验动物模型在体外测量脱髓鞘神经组织的磁共振（MR）参数变化。给断奶大鼠喂食碲（Te）饮食以诱导坐骨神经的脱髓鞘过程。在给予碲饮食后每天测量定量MR参数，如T(1)、T(2)弛豫时间常数和磁化传递（MT）（长达7天），发现这些参数与正常神经的参数有很大不同。观察到平均T(1)和T(2)增加，同时MT比率（MTR）和描述质子半固体池的定量MT参数M(0B)降低。大多数MR参数与通过定量组织病理学评估的神经组织髓鞘分数非常好地相关。T(2)弛豫谱提供了对神经组织微观结构变化最有效的定量评估，其分析产生了一种强大的工具来区分脱髓鞘和炎症过程。相比之下，MT测量不太成功。
