Department of Cardiology, Ernst Moritz Arndt University of Greifswald, Greifswald, Germany.
Eur J Endocrinol. 2010 Oct;163(4):617-23. doi: 10.1530/EJE-10-0563. Epub 2010 Jul 22.
IGF1 mediates multiple physiological and pathophysiological responses in the cardiovascular system. The aim of this study was to analyze the association between serum IGF1 as well as IGF-binding protein 3 (IGFBP3) levels and endothelial function measured by flow-mediated dilation (FMD).
Cross-sectional population-based observational study.
The study population comprised 1482 subjects (736 women) aged 25-85 years from the Study of Health in Pomerania. Serum IGF1 and IGFBP3 levels were determined by chemiluminescence immunoassays. FMD measurements were performed using standardized ultrasound techniques. FMD values below the sex-specific median were considered low.
In males, logistic regression analyses revealed an odds ratio (OR) of 1.27 (95% confidence interval (CI) 1.07-1.51; P=0.008) for decreased FMD for each decrement of IGF1 s.d. after adjustment for major cardiovascular confounders. In females, no significant relationship between serum IGF1 and FMD was found (OR 0.88, CI 0.74-1.05; P=0.147). After exclusion of subjects with the current use of antihypertensive medication, these findings were similar (males: OR 1.40, CI 1.12-1.75; P=0.003; females: OR 0.95, CI 0.77-1.16; P=0.595). There was no association between serum IGFBP3 levels and FMD in both sexes.
Low serum IGF1 levels are associated with impaired endothelial function in males. In women, serum IGF1 is not associated with endothelial function.
IGF1 在心血管系统中介导多种生理和病理生理反应。本研究旨在分析血清 IGF1 和 IGF 结合蛋白 3（IGFBP3）水平与血流介导的扩张（FMD）测量的内皮功能之间的关系。
横断面基于人群的观察性研究。
研究人群包括来自波罗的海健康研究的 1482 名受试者（736 名女性），年龄为 25-85 岁。使用化学发光免疫分析法测定血清 IGF1 和 IGFBP3 水平。使用标准化超声技术进行 FMD 测量。低于性别特异性中位数的 FMD 值被认为是低的。
在男性中，逻辑回归分析显示，IGF1 每降低一个标准差，FMD 降低的优势比（OR）为 1.27（95%置信区间（CI）为 1.07-1.51；P=0.008），调整了主要心血管混杂因素后。在女性中，血清 IGF1 与 FMD 之间没有显著关系（OR 0.88，CI 0.74-1.05；P=0.147）。排除正在使用抗高血压药物的受试者后，这些发现相似（男性：OR 1.40，CI 1.12-1.75；P=0.003；女性：OR 0.95，CI 0.77-1.16；P=0.595）。在两性中，血清 IGFBP3 水平与 FMD 之间均无关联。
低血清 IGF1 水平与男性内皮功能受损有关。在女性中，血清 IGF1 与内皮功能无关。
