Institut National de la Santé et de la Recherche Médicale, Unité 970, Paris Cardiovascular Research Center; Université Paris Descartes, Unité Mixte de Recherche en Santé 970, Paris, France .
Arterioscler Thromb Vasc Biol. 2010 Oct;30(10):2047-52. doi: 10.1161/ATVBAHA.110.208785. Epub 2010 Jul 22.
To examine prospectively the association of high-sensitivity C-reactive protein, interleukin 6, and fibrinogen with sudden death in asymptomatic European men.
Among the 9771 men from the Etude PRospective de l'Infarctus du Myocarde (PRIME) Study, 664 had a first coronary heart disease over 10 years, including 50 sudden deaths, 34 nonsudden coronary deaths, and 580 nonfatal coronary heart disease events. For each outcome, 2 matched controls, who were free of coronary heart disease at the index date, were randomly selected from the initial cohort (nested case control study design). There was a 3-fold increased risk (95% CI, 1.20 to 7.81) of sudden death between the upper and the lower third of interleukin 6 after adjustment for baseline confounders in conditional logistic regression analysis. Neither high-sensitivity C-reactive protein (hazard ratio(third versus first tertile)=1.27; 95% CI, 0.51 to 3.17) nor fibrinogen (hazard ratio(third versus first tertile)=1.90; 95% CI, 0.76 to 4.75) was associated with sudden death. For comparison, there was a 6-fold increased risk of nonsudden coronary death from the highest compared with the lowest tertile of fibrinogen and a trend toward an association with higher C-reactive protein and higher interleukin 6. All 3 inflammatory biomarkers were moderately, but significantly, associated with nonfatal coronary heart disease.
Interleukin 6, but not high-sensitivity C-reactive protein or fibrinogen, is an independent predictor of sudden death in asymptomatic European men.
前瞻性研究超敏 C 反应蛋白、白细胞介素 6 和纤维蛋白原与无症状欧洲男性猝死的相关性。
在 Etude PRospective de l'Infarctus du Myocarde（PRIME）研究的 9771 名男性中，664 人在 10 年内首次发生冠心病，包括 50 例猝死、34 例非猝死性冠心病死亡和 580 例非致死性冠心病事件。对于每种结果，在指数日期无冠心病的 2 名匹配对照者从初始队列中随机选择（巢式病例对照研究设计）。在条件逻辑回归分析中，经调整基线混杂因素后，白细胞介素 6 上三分之一与下三分之一之间的猝死风险增加了 3 倍（95%CI，1.20 至 7.81）。超敏 C 反应蛋白（第三与第一三分位数的危险比=1.27；95%CI，0.51 至 3.17）和纤维蛋白原（第三与第一三分位数的危险比=1.90；95%CI，0.76 至 4.75）均与猝死无关。相比之下，与最低三分位相比，最高三分位的纤维蛋白原与非猝死性冠心病死亡的相关性增加了 6 倍，且与较高的 C 反应蛋白和白细胞介素 6 呈趋势相关。所有 3 种炎症生物标志物与非致死性冠心病中度但显著相关。
白细胞介素 6 而非超敏 C 反应蛋白或纤维蛋白原是无症状欧洲男性猝死的独立预测因子。
Zotero 插件