波形蛋白的异常表达与肝内胆管细胞癌患者的去分化和预后不良相关。

Aberrant expression of vimentin correlates with dedifferentiation and poor prognosis in patients with intrahepatic cholangiocarcinoma.

机构信息

Division of Molecular and Diagnostic Pathology, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, Chuo-ku, Niigata 951-8510, Japan.

出版信息

Anticancer Res. 2010 Jun;30(6):2279-85.

PMID:20651380

Abstract

BACKGROUND

This study aimed to elucidate the prognostic value of vimentin expression in patients with intrahepatic cholangiocarcinoma (ICC).

PATIENTS AND METHODS

A retrospective analysis of 21 patients who underwent resection for ICC was conducted. Vimentin expression was positive when single tumour cells or cell clusters showed immunoreactivity to vimentin, whereas vimentin-negative expression was defined as no detectable expression.

RESULTS

Of the 21 patients, 5 were classified as having tumours with vimentin-positive expression and 16 with vimentin-negative expression. Vimentin-positive expression was more frequent in tumour specimens that were poorly differentiated (4/7; 57%) than in those that were well- or moderately differentiated (1/14; 7%, p=0.025) and was always seen in areas with the highest histological grade. Vimentin-positive expression affected survival adversely, according to univariate (p=0.010) and multivariate analyses (relative risk, 4.294; p=0.047).

CONCLUSION

Vimentin-positive expression correlates with dedifferentiation and predicts poor survival in patients undergoing resection for ICC.

摘要

背景

本研究旨在阐明波形蛋白表达在肝内胆管癌（ICC）患者中的预后价值。

患者和方法

对 21 例接受 ICC 切除术的患者进行回顾性分析。当单个肿瘤细胞或细胞簇对波形蛋白表现出免疫反应时，判定为波形蛋白阳性表达，而波形蛋白阴性表达则定义为未检测到表达。

结果

在 21 例患者中，5 例被归类为波形蛋白阳性表达肿瘤，16 例为波形蛋白阴性表达肿瘤。波形蛋白阳性表达在低分化肿瘤标本中更为常见（4/7；57%），而在高分化或中分化肿瘤标本中则不常见（1/14；7%，p=0.025），并且总是出现在组织学分级最高的区域。根据单因素（p=0.010）和多因素分析（相对风险，4.294；p=0.047），波形蛋白阳性表达与生存不良相关。