Division of Molecular and Diagnostic Pathology, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, Chuo-ku, Niigata 951-8510, Japan.
Anticancer Res. 2010 Jun;30(6):2279-85.
This study aimed to elucidate the prognostic value of vimentin expression in patients with intrahepatic cholangiocarcinoma (ICC).
A retrospective analysis of 21 patients who underwent resection for ICC was conducted. Vimentin expression was positive when single tumour cells or cell clusters showed immunoreactivity to vimentin, whereas vimentin-negative expression was defined as no detectable expression.
Of the 21 patients, 5 were classified as having tumours with vimentin-positive expression and 16 with vimentin-negative expression. Vimentin-positive expression was more frequent in tumour specimens that were poorly differentiated (4/7; 57%) than in those that were well- or moderately differentiated (1/14; 7%, p=0.025) and was always seen in areas with the highest histological grade. Vimentin-positive expression affected survival adversely, according to univariate (p=0.010) and multivariate analyses (relative risk, 4.294; p=0.047).
Vimentin-positive expression correlates with dedifferentiation and predicts poor survival in patients undergoing resection for ICC.
本研究旨在阐明波形蛋白表达在肝内胆管癌(ICC)患者中的预后价值。
对 21 例接受 ICC 切除术的患者进行回顾性分析。当单个肿瘤细胞或细胞簇对波形蛋白表现出免疫反应时,判定为波形蛋白阳性表达,而波形蛋白阴性表达则定义为未检测到表达。
在 21 例患者中,5 例被归类为波形蛋白阳性表达肿瘤,16 例为波形蛋白阴性表达肿瘤。波形蛋白阳性表达在低分化肿瘤标本中更为常见(4/7;57%),而在高分化或中分化肿瘤标本中则不常见(1/14;7%,p=0.025),并且总是出现在组织学分级最高的区域。根据单因素(p=0.010)和多因素分析(相对风险,4.294;p=0.047),波形蛋白阳性表达与生存不良相关。
波形蛋白阳性表达与去分化相关,并预测 ICC 切除术后患者的生存不良。