Enderle J D, Engelken E J, Nelson J
Department of Electrical & Electronics Engineering, North Dakota State University, Fargo 58105.
Biomed Sci Instrum. 1991;27:153-62.
Extracellular single-unit data from the vicinity of the abducens nucleus from rhesus monkeys recorded during horizontal saccades are used as input to an updated oculomotor plant to simulate saccades to test the robustness of the model. Cells recorded from include: Long Lead Burst neurons, Medium Lead Burst neurons, and Burst Tonic neurons. Eye movement position data was collected using the magnetic coil technique. The oculomotor plant used in this study consists of the lateral and medial rectus muscle, and the eyeball. The muscles are modeled as a viscoelastic parallel combination connected to a parallel combination of active state tension generator, viscosity element and length tension elastic element. The eyeball is modeled as a sphere, connected to two parallel viscoelastic elements, connected in series. Each of the elements is linear. All parameters and initial conditions are estimated or directly measured from physiological data. The active state tension generator waveforms are the low-passed filtered motoneural signals. The extracellular single-unit data is used to drive the agonist portion of a neural circuit, consisting of burst, tonic and pause cells. The antagonist portion of the neural activity is based on previously reported characteristics. Simulation results for eye position and higher derivatives are in good agreement with the eye position data and the data derived estimates of higher derivatives.
在水平扫视期间记录的恒河猴展神经核附近的细胞外单单位数据被用作更新后的眼球运动装置的输入，以模拟扫视来测试模型的稳健性。记录的细胞包括：长潜伏期爆发神经元、中潜伏期爆发神经元和爆发张力型神经元。使用磁线圈技术收集眼动位置数据。本研究中使用的眼球运动装置由外直肌和内直肌以及眼球组成。肌肉被建模为粘弹性并联组合，连接到主动状态张力发生器、粘性元件和长度张力弹性元件的并联组合。眼球被建模为一个球体，连接到两个串联的并联粘弹性元件。每个元件都是线性的。所有参数和初始条件均根据生理数据进行估计或直接测量。主动状态张力发生器波形是低通滤波后的运动神经信号。细胞外单单位数据用于驱动由爆发、张力和暂停细胞组成的神经回路的激动剂部分。神经活动的拮抗剂部分基于先前报道的特征。眼位和高阶导数的模拟结果与眼位数据以及高阶导数的数据推导估计值高度一致。
