Department of Molecular Biochemistry and Clinical Investigation, Graduate School Medicine, Osaka University, 1-7 Yamada-oka Suita 565-0871, Japan.
J Oncol. 2010;2010:816595. doi: 10.1155/2010/816595. Epub 2010 Jun 27.
Glycosylation is one of the most common posttranslational modification reactions and nearly half of all known proteins in eukaryotes are glycosylated. In fact, changes in oligosaccharides structures are associated with many physiological and pathological events, including cell growth, migration and differentiation, and tumor invasion. Therefore, functional glycomics, which is a comprehensive study of the structures and functions of glycans, is attracting the increasing attention of scientists in various fields of life science. In cases of thyroid cancer, the biological characters and prognosis are completely different in each type of histopathology, and their oligosaccharide structures as well as the expression of glycosyltransferases are also different. In this review, we summarized our previous papers on oligosaccharides and thyroid cancers and discussed a possible function of oligosaccharides in the carcinogenesis in thyroid cancer.
糖基化是最常见的翻译后修饰反应之一，真核生物中近一半的已知蛋白质都发生了糖基化。事实上，寡糖结构的变化与许多生理和病理事件有关，包括细胞生长、迁移和分化以及肿瘤侵袭。因此，功能糖组学是对聚糖结构和功能的综合研究，正吸引着生命科学各个领域的科学家越来越多的关注。在甲状腺癌中，每种组织病理学类型的生物学特征和预后完全不同，其寡糖结构以及糖基转移酶的表达也不同。在这篇综述中，我们总结了之前关于糖链和甲状腺癌的论文，并讨论了糖链在甲状腺癌发生中的可能功能。
