Broekhuis Jordan M, James Benjamin C, Cummings Richard D, Hasselgren Per-Olof
Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Beth Israel Deaconess Medical Center, National Center for Functional Glycomics, Harvard Medical School, Boston, MA 02215, USA.
Cancers (Basel). 2022 Mar 22;14(7):1610. doi: 10.3390/cancers14071610.
There is evidence that posttranslational modifications, including phosphorylation, acetylation, methylation, ubiquitination, sumoylation, glycosylation, and succinylation, may be involved in thyroid cancer. We review recent reports supporting a role of posttranslational modifications in the tumorigenesis of thyroid cancer, sensitivity to radioiodine and other types of treatment, the identification of molecular treatment targets, and the development of molecular markers that may become useful as diagnostic tools. An increased understanding of posttranslational modifications may be an important supplement to the determination of alterations in gene expression that has gained increasing prominence in recent years.
有证据表明，包括磷酸化、乙酰化、甲基化、泛素化、SUMO化、糖基化和琥珀酰化在内的翻译后修饰可能与甲状腺癌有关。我们综述了最近的报告，这些报告支持翻译后修饰在甲状腺癌肿瘤发生、对放射性碘和其他类型治疗的敏感性、分子治疗靶点的鉴定以及可能作为诊断工具的分子标志物的开发中所起的作用。对翻译后修饰的进一步了解可能是对近年来日益突出的基因表达改变测定的重要补充。
