Doukaki S, Aricò M, Bongiorno M R
Department of Dermatology, University of Palermo, Palermo, Italy.
Case Rep Dermatol. 2009 Oct 27;1(1):60-65. doi: 10.1159/000249148.
Mycosis fungoides (MF) is an uncommon primary cutaneous lymphoma with a wide spectrum of clinicopathological manifestations. Diagnosis can be difficult in its early stages given the considerable overlap with more common benign dermatoses. We report an unusual case of MF in a 52-year-old male presenting with psoriasiform plaques on the palms and the soles who rapidly developed additional lesions on the scalp, limps and trunk. Punch biopsy of the face was obtained for routine histology and immunohistochemical stains. Chest X-ray, total body computed tomography scanning and excisional biopsy of the inguinal lymph node were performed. Review of the face biopsy revealed a diffuse dermal infiltrate containing a high number of atypical lymphocytes showing a CD3+, CD4+, CD45RO+, CD8-, CD20- immunophenotype and epidermotropism. Findings were consistent with tumor stage MF (stage IIB, T3 N1 M0). We report a rare presentation of MF mimicking psoriasis vulgaris.
蕈样肉芽肿(MF)是一种罕见的原发性皮肤淋巴瘤,具有广泛的临床病理表现。鉴于其与更常见的良性皮肤病有相当大的重叠,早期诊断可能具有挑战性。我们报告了一例不寻常的MF病例,患者为一名52岁男性,手掌和脚底出现银屑病样斑块,随后迅速在头皮、四肢和躯干出现其他皮损。对其面部进行了打孔活检,以进行常规组织学和免疫组化染色。还进行了胸部X线检查、全身计算机断层扫描以及腹股沟淋巴结切除活检。面部活检结果显示真皮弥漫性浸润,含有大量非典型淋巴细胞,免疫表型为CD3 +、CD4 +、CD45RO +、CD8 -、CD20 -,且具有亲表皮性。这些发现符合肿瘤期MF(IIB期,T3 N1 M0)。我们报告了一例罕见的MF表现,类似寻常型银屑病。