Alnasser Monira Abdullah, AlKhawajah Nour Marwan, AlQadri Nada Ghazi, Shadid Asem Mustafa, Alsaif Fahad M
Department of Dermatology, King Fahad Medical City, Riyadh, Saudi Arabia.
Department of Dermatology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Case Rep Oncol. 2021 Mar 2;14(1):256-261. doi: 10.1159/000512822. eCollection 2021 Jan-Apr.
Cutaneous T-cell lymphoma (CTCL) describes a group of lymphoproliferative disorders characterized by localization of neoplastic T lymphocytes to the skin. Mycosis fungoides (MF) represents the most common type of CTCL and accounts for ∼60% of all primary cutaneous lymphomas. Apart from the classic type of MF, many clinical and histopathologic variants have been described. The malignant lymphocytes in MF are usually CD3, CD4 and CD45RO positive and CD8 negative. An unusual immunohistochemical profile of a CD4-negative and CD8-positive mature T-cell phenotype has been reported in a minority of patients; up to 20% of early-stage MF demonstrates a CD8-positive phenotype. There are only a few cases of a double-negative CD4/CD8 MF phenotype reported in the literature. We present the case of a 60-year-old male presenting a double-negative CD4/CD8 MF phenotype.
皮肤T细胞淋巴瘤（CTCL）是一组以肿瘤性T淋巴细胞定位于皮肤为特征的淋巴增殖性疾病。蕈样肉芽肿（MF）是CTCL最常见的类型，占所有原发性皮肤淋巴瘤的约60%。除了经典类型的MF外，还描述了许多临床和组织病理学变异型。MF中的恶性淋巴细胞通常CD3、CD4和CD45RO阳性，CD8阴性。少数患者报告了一种不寻常的免疫组化特征，即CD4阴性和CD8阳性的成熟T细胞表型；高达20%的早期MF表现为CD8阳性表型。文献中仅报道了少数几例双阴性CD4/CD8 MF表型的病例。我们报告了一例表现为双阴性CD4/CD8 MF表型的60岁男性病例。
