米非司酮给药后 24 小时口服与舌下含服米索前列醇用于药物流产的随机试验。
Randomized trial of oral versus sublingual misoprostol 24 h after mifepristone for medical abortion.
机构信息
Department of Obstetrics and Gynecology, Pt. B.D. Sharma PGIMS Rohtak, Rohtak, 124001, Haryana, India.
出版信息
Arch Gynecol Obstet. 2011 Jul;284(1):59-63. doi: 10.1007/s00404-010-1590-2. Epub 2010 Jul 22.
OBJECTIVES
To assess the efficacy, side effects, and acceptability of medical abortion using oral mifepristone (200 mg) followed 24 h later by oral or sublingual misoprostol (400 μg).
MATERIALS AND METHODS
A total of 93 women with pregnancies up to 56 days of gestational age were assigned to two groups according to the different misoprostol regimen (group I 400 μg orally and group II 400 μg sublingually). The principle outcome measure was complete abortion defined as a complete expulsion of intrauterine contents without a need for surgical intervention 7 days after the procedure.
RESULTS
Successful abortion occurred in 87.5% of patients in group 1 and 95.5% patients in group 2 (p = 0.166, 95% CI -0.194, 0.033). The patient acceptability and satisfaction rates were similar in both the groups.
CONCLUSION
It is concluded that 400 μg of sublingual misoprostol is as effective as oral misoprostol 24 h after mifepristone for medical abortion of ≤ 56 days.
目的
评估米非司酮（200mg）口服后 24 小时后再口服或舌下给予米索前列醇（400μg）用于药物流产的疗效、副作用和可接受性。
材料和方法
将 93 名妊娠时间不超过 56 天的妇女根据不同的米索前列醇方案（I 组 400μg 口服和 II 组 400μg 舌下）分为两组。主要结局测量是指在手术后 7 天内无需手术干预即可完全排出宫内内容物的完全流产。
结果
I 组 87.5%的患者和 II 组 95.5%的患者成功流产（p=0.166，95%CI-0.194，0.033）。两组患者的接受度和满意度相似。
结论
结论是，在米非司酮后 24 小时，400μg 舌下米索前列醇与口服米索前列醇用于≤56 天的药物流产同样有效。
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