Tang Oi Shan, Chan Carina C W, Kan Anita S Y, Ho Pak Chung
Department of Obstetrics and Gynaecology, The University of Hong Kong, Queen Mary Hospital, Hong Kong SAR, China.
Hum Reprod. 2005 Nov;20(11):3062-6. doi: 10.1093/humrep/dei196. Epub 2005 Jul 21.
Sublingual misoprostol has been shown to be effective in medical abortion. A prospective double-blinded placebo-controlled trial was done to compare the efficacy and side-effects of sublingual to oral misoprostol when used with mifepristone for medical abortion from 12 to 20 weeks gestation.
A total of 120 women at 12-20 weeks of gestation were randomized to receive 200 mg oral mifepristone followed by either sublingual or oral misoprostol 400 mg every 3 h for a maximum of five doses 36-48 h later. The course of misoprostol was repeated if the woman did not abort within 24 h.
There was no significant difference (P = 0.43) in the success rate at 24 h [relative risk = 1.075; 95% confidence interval (CI): 0.94-1.19]. Abortion occurred in 91.4% in the sublingual group (95% CI: 81.0-96.7%) as compared to 85.0% (95% CI: 73.7-92.1%) in the oral group. The median induction-to-abortion interval was significantly shorter (P = 0.009) in the sublingual group (5.5 h) as compared to the oral group (7.5 h). The incidence of fever was higher in the sublingual group (P < 0.0001). The incidences of other side-effects were similar.
Sublingual misoprostol, when combined with mifepristone, is effective for medical abortion in the second trimester. The induction-to-abortion interval is shorter when sublingual misoprostol is used when compared to oral misoprostol.
已证明米索前列醇舌下含服在药物流产中有效。进行了一项前瞻性双盲安慰剂对照试验，以比较米索前列醇舌下含服与口服在与米非司酮联合用于妊娠12至20周药物流产时的疗效和副作用。
总共120名妊娠12至20周的妇女被随机分组，先口服200毫克米非司酮，随后每3小时舌下含服或口服400毫克米索前列醇，最多服用五剂，36至48小时后进行。如果妇女在24小时内未流产，则重复米索前列醇疗程。
24小时成功率无显著差异（P = 0.43）[相对危险度 = 1.075；95%置信区间（CI）：0.94 - 1.19]。舌下含服组流产率为91.4%（95%CI：81.0 - 96.7%），口服组为85.0%（95%CI：73.7 - 92.1%）。与口服组（7.5小时）相比，舌下含服组诱导至流产的中位间隔时间显著更短（P = 0.009）（5.5小时）。舌下含服组发热发生率更高（P < 0.0001）。其他副作用发生率相似。
米索前列醇舌下含服与米非司酮联合用于中期妊娠药物流产有效。与口服米索前列醇相比，舌下含服米索前列醇时诱导至流产的间隔时间更短。
