Xuereb J H, Perry R H, Candy J M, Perry E K, Marshall E, Bonham J R
Department of Morbid Anatomy and Histopathology, Addenbrookes Hospital, Cambridge, UK.
Brain. 1991 Jun;114 ( Pt 3):1363-79.
Serial sections through the thalamus from the fixed right cerebral hemispheres of 15 cases (5 Parkinson's disease, 5 Alzheimer's disease (AD) and 5 controls) were used to obtain quantitative estimates of neuronal loss, neurofibrillary tangle formation and Lewy body inclusions within individual thalamic nuclei. Severe neuronal loss and tangle formation were evident in the anterodorsal nucleus from the AD cases. Nerve cell damage was also present in the centromedian nucleus but was not associated with tangle formation and occurred in all but 2 of the brains examined. It is likely that the anterodorsal neurons are damaged locally by the Alzheimer's disease process whereas the changes in the centromedian nucleus may be related to ageing.
对15例（5例帕金森病、5例阿尔茨海默病（AD）和5例对照）固定的右侧大脑半球的丘脑进行连续切片，以获得各个丘脑核团内神经元丢失、神经原纤维缠结形成和路易小体包涵体的定量估计。AD病例的前背侧核中明显存在严重的神经元丢失和缠结形成。中央中核也存在神经细胞损伤，但与缠结形成无关，在所检查的所有大脑中，除2例外均有发生。前背侧神经元很可能在局部被阿尔茨海默病进程破坏，而中央中核的变化可能与衰老有关。
