School of Mathematics and Statistics, Shaanxi Normal University, Xi'an, 710062, People's Republic of China.
School of Mathematics and Statistics, Northwestern Polytechnical University, Xi'an, 710072, People's Republic of China.
Sci Rep. 2023 Mar 1;13(1):3495. doi: 10.1038/s41598-023-30535-w.
Decreased coherence in electroencephalogram (EEG) has been reported in Alzheimer's disease (AD) experimentally, which could be considered as a typical electrophysiological characteristic in AD. This work aimed to investigate the effect of AD on coherence in the dorsal visual pathway by the technique of neurocomputation. Firstly, according to the hierarchical organization of the cerebral cortex and the information flows of the dorsal visual pathway, a more physiologically plausible neural mass model including cortical areas v1, v2, and v5 was established in the dorsal visual pathway. The three interconnected cortical areas were connected by ascending and descending projections. Next, the pathological condition of loss of long synaptic projections in AD was simulated by reducing the parameters of long synaptic projections in the model. Then, the loss of long synaptic projections on coherence among different visual cortex areas was explored by means of power spectral analysis and coherence function. The results demonstrate that the coherence between these interconnected cortical areas showed an obvious decline with the gradual decrease of long synaptic projections, i.e. decrease in descending projections from area v2 to v1 and v5 to v2 and ascending projection from area v2 to v5. Hopefully, the results of this study could provide theoretical guidance for understanding the dynamical mechanism of AD.
脑电图（EEG）中的相干性降低已在实验性阿尔茨海默病（AD）中报道，这可以被认为是 AD 的典型电生理特征。本工作旨在通过神经计算技术研究 AD 对背侧视觉通路相干性的影响。首先，根据大脑皮层的层次组织和背侧视觉通路的信息流，在背侧视觉通路中建立了一个包括皮质区 v1、v2 和 v5 的更符合生理的神经质量模型。这三个相互连接的皮质区通过上行和下行投射连接。接下来，通过降低模型中长突触投射的参数来模拟 AD 中长突触投射丧失的病理情况。然后，通过功率谱分析和相干函数来探讨 AD 中长突触投射丧失对不同视觉皮质区之间相干性的影响。结果表明，随着长突触投射的逐渐减少，这些相互连接的皮质区之间的相干性明显下降，即来自 v2 到 v1 和 v5 到 v2 的下行投射以及来自 v2 到 v5 的上行投射减少。希望本研究的结果能为理解 AD 的动力学机制提供理论指导。
