Vandenberghe E, de Wolf-Peeters C, Delabie J, Thomas J, Michaux J L, Noël H, Mecucci C, Van Den Berghe H
Center for Human Genetics, Leuven, Belgium.
Cancer Genet Cytogenet. 1991 Jun;53(2):229-35. doi: 10.1016/0165-4608(91)90099-g.
We report the cytogenetic results in three cases of B-cell non-Hodgkin's lymphomas with morphologic and immunophenotypic features compatible with a non-follicle center cell lymphoma. In all cases, a chromosome breakpoint at 14q32 and structural abnormalities of 1p were found. Increased copies of chromosome segment 12q and structural rearrangements of chromosome 6 were found in two cases. Translocation (14;18)(q32;q21) with rearrangement of bcl-2 was found in one case. These lymphomas have a perifollicular growth pattern and IgM+, IgD+, CD10-, and CD22+ immunophenotype features typical of non-follicle center cell lymphomas and probably belong to the follicle mantle lymphomas described recently. Little cytogenetic data about this group of lymphomas is available, possibly because in the Working Formulation for the Classification of Lymphomas they are not separated from follicle center cell lymphomas.
我们报告了3例B细胞非霍奇金淋巴瘤的细胞遗传学结果，其形态学和免疫表型特征与非滤泡中心细胞淋巴瘤相符。在所有病例中，均发现14q32处的染色体断裂点以及1p的结构异常。2例病例中发现12q染色体片段拷贝数增加以及6号染色体的结构重排。1例病例中发现伴有bcl-2重排的(14;18)(q32;q21)易位。这些淋巴瘤具有滤泡周围生长模式以及非滤泡中心细胞淋巴瘤典型的IgM+、IgD+、CD10-和CD22+免疫表型特征，可能属于最近描述的滤泡套淋巴瘤。关于这组淋巴瘤的细胞遗传学数据很少，可能是因为在淋巴瘤分类工作方案中它们未与滤泡中心细胞淋巴瘤区分开来。
