Wlodarska I, Mecucci C, Vandenberghe E, De Wolf-Peeters C, Thomas J, Hilliker C, Schoenmakers E, Stul M, Marynen P, Cassiman J J
Center for Human Genetics, University of Leuven, Belgium.
Genes Chromosomes Cancer. 1992 Jun;4(4):302-8. doi: 10.1002/gcc.2870040405.
Two t(14;18)-negative follicular B-non-Hodgkin's lymphomas with the same chromosomal abnormality, dup(12)(q13----qter), are presented. The absence of a BCL2 gene rearrangement was confirmed by molecular studies in both cases. Instead, duplication of a 12q segment was found. Further evidence for the presence of the dup(12)(q13----qter) was found using fluorescence in situ hybridization. dup(12q) may be equivalent to the trisomy 12 originally described in B-chronic lymphocytic leukemia. This chromosome anomaly has also been reported in B-non-Hodgkin's lymphomas, usually in association with other chromosome anomalies and a more aggressive tumor phenotype. Occurrence of dup(12q) in two histologically similar cases of follicular small cleaved-cell lymphoma without a typical t(14;18), suggests that this karyotypic change may play a critical role in some cases of follicle center-cell lymphomas.
本文报告了两例具有相同染色体异常dup(12)(q13----qter)的t(14;18)阴性滤泡性B细胞非霍奇金淋巴瘤。两例均经分子研究证实不存在BCL2基因重排。相反，发现了12q节段的重复。使用荧光原位杂交进一步证实了dup(12)(q13----qter)的存在。dup(12q)可能等同于最初在B细胞慢性淋巴细胞白血病中描述的12号染色体三体。这种染色体异常也在B细胞非霍奇金淋巴瘤中被报道，通常与其他染色体异常及更具侵袭性的肿瘤表型相关。在两例组织学相似的无典型t(14;18)的滤泡性小裂细胞淋巴瘤中出现dup(12q)，提示这种核型改变可能在某些滤泡中心细胞淋巴瘤病例中起关键作用。
