Department of Psychiatry, University Hospital, 70210 Kuopio, Finland.
Psychiatry Clin Neurosci. 2010 Aug;64(4):387-93. doi: 10.1111/j.1440-1819.2010.02111.x.
Both the serotonin transporter and its genetic regulation by the serotonin-transporter-linked polymorphic region have a role in the pathophysiology of depression. Most of the previous studies have found no influence of serotonin-transporter-linked polymorphic region allelic variation on serotonin transporter binding in healthy controls or patients with major depression. Due to the inconsistency of the previous findings, we compared single photon emission computed tomography imaging with the serotonin-transporter-linked polymorphic region genotype in patients with major depressive disorder.
A total of 23 drug-naïve patients with major depressive disorder were genotyped and brain imaged with ([123I])nor-beta-CIT single photon emission computed tomography. The severity of depression was evaluated with the 17-item Hamilton depression rating scale.
Depressed patients homozygous for the short allele had lower ([123I])nor-beta-CIT binding in the medial prefrontal cortex, but not in the midbrain, compared with the other genotypes.
The decreased medial prefrontal cortical serotonin transporter binding in the patients homozygous for the short allele may be linked to altered function of the serotonin-transporter-linked polymorphic region gene expressed in these patients, especially in the medial prefrontal cortex.
血清素转运体及其基因调控的血清素转运体连接多态性区域在抑郁症的病理生理学中都起着一定的作用。之前的大多数研究都发现血清素转运体连接多态性区域等位基因变异对健康对照者或重度抑郁症患者的血清素转运体结合没有影响。由于之前的研究结果不一致，我们比较了单光子发射计算机断层扫描成像与重度抑郁症患者的血清素转运体连接多态性区域基因型。
对 23 名未经药物治疗的重度抑郁症患者进行基因分型，并使用[123I]β-CIT 单光子发射计算机断层扫描进行脑部成像。使用汉密尔顿抑郁量表的 17 项对抑郁的严重程度进行评估。
与其他基因型相比，短等位基因纯合的抑郁患者在中脑前额叶皮质的[123I]β-CIT 结合较低。
短等位基因纯合的患者中中前额叶皮质血清素转运体结合的减少可能与这些患者中表达的血清素转运体连接多态性区域基因的功能改变有关，尤其是在中前额叶皮质。
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