Department of Neurology and Neurosurgery, University of Tartu, 8 L, Puusepa St,, 51014 Tartu, Estonia.
BMC Neurol. 2013 Dec 17;13:204. doi: 10.1186/1471-2377-13-204.
Purpose of the study was to investigate alterations in midbrain serotonin transporter (SERT) binding in patients with epilepsy and symptoms of depression compared to patients with epilepsy with no symptoms of depression.
We studied 12 patients with epilepsy (7 patients had focal and 5 had generalized epilepsy syndromes). The presence of self-reported symptoms of depression was assessed using Beck Depression Inventory (BDI) and the Emotional State Questionnaire (EST-Q). The binding potential of the SERT was assessed by performing brain single photon emission tomography (SPET) using the SERT radioligand 2-((2-((dimethylamino)methyl)phenyl)thio)-5-(123)iodophenylamine (123I-ADAM).
Seven patients had BDI and EST-Q subscale scores greater than 11 points, which was interpreted as the presence of symptoms of depression. We found that 123I-ADAM binding was not significantly different between patients with epilepsy with and without symptoms of depression. In addition, 123I-ADAM binding did not show a significant correlation to either BDI or EST-Q depression subscale scores and did not differ between patients with focal vs. generalized epilepsy.
The results of our study failed to demonstrate alterations of SERT binding properties in patients with epilepsy with or without symptoms of depression.
本研究旨在探讨与无抑郁症状的癫痫患者相比，伴抑郁症状的癫痫患者的中脑 5-羟色胺转运体（SERT）结合的变化。
我们研究了 12 名癫痫患者（7 名局灶性癫痫患者和 5 名全面性癫痫综合征患者）。使用贝克抑郁量表（BDI）和情绪状态问卷（EST-Q）评估了自我报告的抑郁症状的存在。通过使用 SERT 放射性配体 2-（（2-（二甲氨基）甲基）苯基）硫代-5-（123）碘代苯乙胺（123I-ADAM）进行脑单光子发射断层扫描（SPET）来评估 SERT 的结合能力。
7 名患者的 BDI 和 EST-Q 亚量表评分大于 11 分，这被解释为存在抑郁症状。我们发现，有和无抑郁症状的癫痫患者之间 123I-ADAM 结合没有显著差异。此外，123I-ADAM 结合与 BDI 或 EST-Q 抑郁亚量表评分均无显著相关性，且局灶性与全面性癫痫患者之间也无差异。
我们的研究结果未能证明有或无抑郁症状的癫痫患者 SERT 结合特性发生改变。
