School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China.
Chin Med. 2010 Jul 25;5:26. doi: 10.1186/1749-8546-5-26.
Multi-drug resistance (MDR) of cancer cells severely limits therapeutic outcomes. A proposed mechanism for MDR involves the efflux of anti-cancer drugs from cancer cells, primarily mediated by ATP-binding cassette (ABC) membrane transporters including P-glycoprotein. This article reviews the recent progress of using active ingredients, extracts and formulae from Chinese medicine (CM) in circumventing ABC transporters-mediated MDR. Among the ABC transporters, Pgp is the most extensively studied for its role in MDR reversal effects. While other MDR reversal mechanisms remain unclear, Pgp inhibition is a criterion for further mechanistic study. More mechanistic studies are needed to fully establish the pharmacological effects of potential MDR reversing agents.
癌细胞的多药耐药（MDR）严重限制了治疗效果。一种提出的 MDR 机制涉及癌细胞中外排抗癌药物，主要由 ATP 结合盒（ABC）膜转运体介导，包括 P-糖蛋白。本文综述了利用中药（CM）的活性成分、提取物和配方来规避 ABC 转运体介导的 MDR 的最新进展。在 ABC 转运体中，Pgp 因其在逆转 MDR 作用中的作用而被广泛研究。虽然其他 MDR 逆转机制尚不清楚，但 Pgp 抑制是进一步进行机制研究的标准。需要进行更多的机制研究，以充分确定潜在的 MDR 逆转剂的药理作用。
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