德国野猪群体中猪呼肠孤病毒的高流行率。
High prevalence of porcine Hokovirus in German wild boar populations.
机构信息
Robert Koch-Institut, Centre for Biological Security ZBS1, Nordufer 20, Berlin, Germany.
出版信息
Virol J. 2010 Jul 25;7:171. doi: 10.1186/1743-422X-7-171.
Porcine Hokovirus (PHoV) was recently discovered in Hong Kong. This new Parvovirus of pigs is closely related to the human Parvoviruses 4 and 5 (PARV4/5) and bovine Hokovirus (BHoV). So far, nothing is known about the presence and prevalence of PHoV in regions of the world other than Hong Kong. A study was initiated to investigate PHoV in German wild boars from five different geographical regions, using a newly established quantitative real-time PCR assay. Analysis of collected liver and serum samples revealed high overall prevalence (32.7%; 51/156) of PHoV in wild boars. The prevalence differed between the regions and increased with age. Two near full-length genomes and a large fragment for three additional isolates from different regions were sequenced and used for phylogenetic analysis. The German PHoV sequences from wild boars showed a close relationship with sequences of isolates from Hong Kong.
猪源细小病毒（PHoV）最近在香港被发现。这种新型猪细小病毒与人类细小病毒 4 型和 5 型（PARV4/5）以及牛源细小病毒（BHoV）密切相关。迄今为止，除香港以外的其他地区尚未发现 PHoV 的存在和流行情况。本研究使用新建立的定量实时 PCR 检测方法，对来自德国五个不同地理区域的野猪中的 PHoV 进行了研究。对收集的肝脏和血清样本进行分析显示，野猪中 PHoV 的总流行率较高（32.7%；51/156）。不同地区的流行率存在差异，并随年龄增长而增加。对来自不同地区的另外三个分离株的两个近乎全长基因组和一个较大片段进行了测序，并用于系统发育分析。来自野猪的德国 PHoV 序列与来自香港的分离株序列密切相关。
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