Vargas-Bermudez Diana S, Diaz Andres, Polo Gina, Mogollon Jose Dario, Jaime Jairo
Universidad Nacional de Colombia, Sede Bogotá, Facultad de Medicina Veterinaria y de Zootecnia, Departamento de Salud Animal, Centro de Investigación en Infectología e Inmunología Veterinaria-CI3V.Cra. 30 # 45-03, Bogotá 11001, Colombia.
Pig Improvement Company, Hendersonville, TN 37075, USA.
Vet Sci. 2024 Apr 24;11(5):185. doi: 10.3390/vetsci11050185.
Seven novel porcine parvoviruses (nPPVs) (PPV2 through PPV8) have been described, although their pathogenicity and possible effects on porcine reproductive failure (PRF) are undefined. In this study, these nPPVs were assessed in gilts from Colombia; their coinfections with PPV1, PCV2, PCV3, PCV4, and PRRSV and an association between the nPPVs and the reproductive performance parameters (RPPs) in sows were determined. For this, 234 serum samples were collected from healthy gilts from 40 herds in five Colombian regions, and the viruses were detected via real-time PCR. The results confirmed the circulation of PPV2 through PPV7 in Colombia, with PPV3 (40%), PPV5 (20%), and PPV6 (17%) being the most frequent. Additionally, no PCV4 or PPV8 was detected. PPV2 to PPV7 were detected in concurrence with each other and with the primary PRF viruses, and these coinfections varied from double to sextuple coinfections. Additionally, the association between nPPVs and PRF primary viruses was statistically significant for the presence of PPV6 in PCV3-positive ( < 0.01) and PPV5 in PPRSV-positive ( < 0.05) gilts; conversely, there was a significant presence of PPV3 in both PCV2-negative ( < 0.01) and PRRSV-negative ( < 0.05) gilts. Regarding the RPPs, the crude association between virus detection (positive or negative) and a high or low RPP was only statistically significant for PCV3 and the farrowing rate (FR), indicating that the crude odds of a low FR were 94% lower in herds with PCV3-positive gilts. This finding means that the detection of PCV3 in gilts (PCV3-positive by PCR) is associated with a higher FR in the farm or that these farms (with positive gilts) have lower odds (OR 0.06, -value 0.0043) of a low FR. Additionally, a low FR tended to be associated with the detection of PPV4 and PPV5 (-value < 0.20). This study is important for establishing the possible participation of nPPVs in PRF.
已经描述了七种新型猪细小病毒（nPPV）（PPV2至PPV8），尽管它们的致病性以及对猪繁殖障碍（PRF）的可能影响尚不清楚。在本研究中，对来自哥伦比亚的后备母猪中的这些nPPV进行了评估；确定了它们与PPV1、PCV2、PCV3、PCV4和PRRSV的混合感染以及nPPV与母猪繁殖性能参数（RPP）之间的关联。为此，从哥伦比亚五个地区40个猪群的健康后备母猪中收集了234份血清样本，并通过实时PCR检测病毒。结果证实PPV2至PPV7在哥伦比亚存在传播，其中PPV3（40%）、PPV5（20%）和PPV6（17%）最为常见。此外，未检测到PCV4或PPV8。PPV2至PPV7相互之间以及与主要的PRF病毒同时被检测到，这些混合感染从双重感染到六重感染不等。此外，对于PCV3阳性后备母猪中PPV6的存在（<0.01）以及PRRSV阳性后备母猪中PPV5的存在（<0.05），nPPV与PRF主要病毒之间的关联具有统计学意义；相反，在PCV2阴性（<0.01）和PRRSV阴性（<0.05）的后备母猪中，PPV3的存在均具有显著意义。关于RPP，病毒检测（阳性或阴性）与高或低RPP之间的粗略关联仅在PCV3和产仔率（FR）方面具有统计学意义，这表明在PCV3阳性后备母猪的猪群中，低FR的粗略几率低94%。这一发现意味着在后备母猪中检测到PCV3（PCR检测为PCV3阳性）与猪场中较高的FR相关，或者这些猪场（后备母猪为阳性）出现低FR的几率较低（OR 0.06，P值0.0043）。此外，低FR倾向于与PPV4和PPV5的检测相关（P值<0.20）。本研究对于确定nPPV在PRF中可能的作用具有重要意义。
