Wang Wei, Wu Ping-sheng, Yang Xi-li
Department of Cardiology, Nanfang Hospital, Guangzhou 510515, China.
Zhonghua Xin Xue Guan Bing Za Zhi. 2010 May;38(5):411-4.
To compare right atrial structural remodeling and the expression of matrix metalloproteinase (MMP) and tissue inhibitors (TIMP) between patients with unstable angina (UA) and myocardial infarction (MI).
Right atrial appendages were obtained from 18 patients with UA and 22 patients with MI undergoing coronary artery bypass grafting (CABG) operations. MMP-1, -3, -7, -9 and TIMP-1 protein expressions were detected by immunohistochemistry and RT-PCR. Echocardiography was performed before CABG.
The left and right atrial diameter, left ventricular diameter and mRNA levels of MMP-3, MMP-9 and TIMP-1 were significantly higher in MI group than those in UA group [LAD: (40.8 +/- 4.2) mm vs. (33.1 +/- 5.1) mm, P < 0.01; RAD: (44.1 +/- 6.8) mm vs. (28.8 +/- 6.0) mm, P < 0.01; LVEDD: (48.9 +/- 6.0) mm vs. (39.7 +/- 7.1) mm, P < 0.05; MMP-3: 0.39 +/- 0.18 vs. 0.28 +/- 0.07, P < 0.05; MMP-9: 0.81 +/- 0.21 vs. 0.55 +/- 0.20, P < 0.01; TIMP-1: 1.79 +/- 0.89 vs. 0.94 +/- 0.47, P < 0.01]. MMP-1, MMP-7 levels were similar between the 2 groups (MMP-1: 0.14 +/- 0.06 vs. 0.10 +/- 0.08, P > 0.05; MMP-7: 0.25 +/- 0.05 vs. 0.23 +/- 0.06, P > 0.05).
Right atrial up-regulation of MMP-3, MMP-9 and TIMP-1 levels may contribute to the right atrial structural remodeling in MI patients.
比较不稳定型心绞痛（UA）患者与心肌梗死（MI）患者右心房结构重塑以及基质金属蛋白酶（MMP）和组织抑制剂（TIMP）的表达情况。
获取18例行冠状动脉旁路移植术（CABG）的UA患者和22例行CABG的MI患者的右心耳。采用免疫组织化学和逆转录-聚合酶链反应（RT-PCR）检测MMP-1、-3、-7、-9和TIMP-1蛋白表达。在CABG术前进行超声心动图检查。
MI组的左、右心房直径、左心室直径以及MMP-3、MMP-9和TIMP-1的mRNA水平显著高于UA组[左心房直径：（40.8±4.2）mm对（33.1±5.1）mm, P<0.01；右心房直径：（44.1±6.8）mm对（28.8±6.0）mm, P<0.01；左心室舒张末期内径：（48.9±6.0）mm对（39.7±7.1）mm, P<0.05；MMP-3：0.39±0.18对0.28±0.07, P<0.05；MMP-9：0.81±0.21对0.55±0.20, P<0.01；TIMP-1：1.79±0.89对0.94±0.47, P<0.01]。两组间MMP-1、MMP-7水平相似（MMP-1：0.14±0.06对0.10±0.08, P>0.05；MMP-7：0.25±0.05对0.23±0.06, P>0.05）。
MI患者右心房中MMP-3、MMP-9和TIMP-1水平上调可能导致右心房结构重塑。
