毋庸置疑：胰岛素调节骨骼重塑。
No bones about it: insulin modulates skeletal remodeling.
机构信息
Maine Medical Center Research Institute, Scarborough, ME 04074, USA.
出版信息
Cell. 2010 Jul 23;142(2):198-200. doi: 10.1016/j.cell.2010.07.001.
PMID:20655463
Abstract
Advancing the hypothesis that bone remodeling is intimately linked to metabolic homeostasis, Fulzele et al. (2010) and Ferron et al. (2010) present evidence that insulin signaling promotes the activation of bone-forming osteoblasts and enhances production of osteocalcin, a secreted mediator of insulin sensitivity, through modulation of bone resorption.
摘要
福兹尔等人（2010 年）和费龙等人（2010 年）提出假设，即骨重塑与代谢稳态密切相关，并提出证据表明，胰岛素信号通过调节骨吸收促进骨形成的成骨细胞的激活，并增强骨钙素的产生，骨钙素是胰岛素敏感性的一种分泌介质。
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