Booth Sarah L, Centi Amanda J, Gundberg Caren
Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA, 02111, USA,
Curr Diab Rep. 2014 Dec;14(12):556. doi: 10.1007/s11892-014-0556-3.
There are well-established associations between diabetes and fracture risk and yet the mechanism underlying these associations are controversial. Guided by a series of mouse studies, a specific form of the bone protein, osteocalcin, was proposed to be the mechanistic link between these two chronic diseases. Translation to humans initially appeared elusive in part because serum concentrations of osteocalcin are a biomarker of bone turnover and not necessarily specific to the biology of this protein. The suitability of the mouse model for the study of osteocalcin as a therapeutic target also appears ambiguous. With greater discrimination of the different forms of osteocalcin present in circulation and inclusion of multiple measures of bone turnover, evidence currently does not support osteocalcin as a protein critical to the diabetes and fracture association in humans.
糖尿病与骨折风险之间存在已被充分证实的关联，然而这些关联背后的机制仍存在争议。在一系列小鼠研究的指导下，一种特定形式的骨蛋白——骨钙素，被认为是这两种慢性疾病之间的机制性联系。最初向人类的转化似乎难以实现，部分原因是血清骨钙素浓度是骨转换的生物标志物，不一定特定于这种蛋白质的生物学特性。小鼠模型作为研究骨钙素作为治疗靶点的适用性也似乎不明确。随着对循环中存在的不同形式骨钙素的更精确区分以及纳入多种骨转换测量指标，目前的证据并不支持骨钙素是人类糖尿病与骨折关联中的关键蛋白质。
