Immunology and Allergy Unit, Wolfson Medical Center, Holon, Israel.
Autoimmun Rev. 2010 Nov;10(1):46-50. doi: 10.1016/j.autrev.2010.07.005. Epub 2010 Jul 23.
To review and update drug-induced lupus (DIL) with emphasis on the characteristics of anti-TNF-induced lupus.
DIL is an autoimmune phenomenon triggered by a given drug and resulting in a syndrome sharing several features of systemic lupus erythematosus (SLE). Drugs like procainamide and hydralazine have been strongly associated with the development of DIL. During the past years several cases of DIL related to biologic therapy with anti-TNF drugs were reported. From the analysis of the unusual characteristics of these cases some conclusions may be drawn: anti-TNF-induced DIL may present with classical SLE dermatologic symptoms, hypocomplementemia, an increased frequency of significant anti-dsDNA antibody titers and a decreased incidence of anti-histone antibodies, all these atypical findings in classical DIL.
Anti-TNF-induced DIL may be a unique form of the disease or may possibly result from the unmasking of latent idiopathic SLE.
综述药物诱导性狼疮（DIL），重点阐述抗 TNF 诱导性狼疮的特征。
DIL 是一种由特定药物引发的自身免疫现象，其表现为具有系统性红斑狼疮（SLE）多种特征的综合征。普鲁卡因胺和肼屈嗪等药物与 DIL 的发生有密切关系。近年来，有几例与抗 TNF 生物治疗相关的 DIL 病例报告。对这些病例的特殊特征进行分析后可以得出一些结论：抗 TNF 诱导性 DIL 可能表现为典型 SLE 的皮肤症状、低补体血症、高频率出现有意义的抗 dsDNA 抗体滴度和低频率出现抗组蛋白抗体，所有这些均为典型 DIL 中的非典型表现。
抗 TNF 诱导性 DIL 可能是一种独特的疾病形式，也可能是潜在特发性 SLE 被揭示的结果。
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