Tanaka Tomotaka, Hirano Daiki, Ishimaru Syohei, Arataki Keiko
Department of Gastroenterology, Tsuchiya General Hospital, Hiroshima, JPN.
Cureus. 2024 Nov 29;16(11):e74782. doi: 10.7759/cureus.74782. eCollection 2024 Nov.
A 46-year-old man with a known case of Crohn's disease, which developed in August 2010, had been in remission since then with infliximab treatment. However, in November 2023, he developed photosensitivity, followed by joint pain and general fatigue in December. Blood tests revealed positive antinuclear antibodies, leading to a diagnosis of drug-induced lupus. After switching from infliximab to vedolizumab, his symptoms improved, and antinuclear antibodies became negative. We present a case of Crohn's disease in which drug-induced lupus developed after approximately 14 years of infliximab treatment. Cases of drug-induced lupus developing from long-term administration of tumor necrosis factor alpha (TNFα) inhibitors are rare, so we report this case with a literature review.
一名46岁男性，已知患有克罗恩病，该病于2010年8月发病，自那时起接受英夫利昔单抗治疗后病情一直缓解。然而，2023年11月，他出现了光敏反应，随后在12月出现关节疼痛和全身乏力。血液检查显示抗核抗体呈阳性，导致诊断为药物性狼疮。从英夫利昔单抗换用维多珠单抗后，他的症状有所改善，抗核抗体转为阴性。我们报告一例克罗恩病患者，在接受英夫利昔单抗治疗约14年后发生了药物性狼疮。长期使用肿瘤坏死因子α（TNFα）抑制剂导致药物性狼疮的病例罕见，因此我们报告此病例并进行文献复习。
